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On January 11, 2022, " Protein & Cell " published online the latest achievements of Sun Fei's group from the State Key Laboratory of Biomacromolecules and Zhang Chuanmao's group from Peking University in the study of the outer ring structure of the nuclear pore complex of Xenopus laevis"8 Å structure of the outer rings of the Xenopus laevis nuclear pore complex obtained by cryo-EM and AI"
The nucleus is the largest organelle in eukaryotic cells, and on the nuclear membrane there are pores that communicate the transport of nucleoplasmic and cytoplasmic substances and energy, called the nuclear pore complex
Sun Fei's research group and Zhang Chuanmao's research group of Peking University have further developed cryo-electron microscopy single particle analysis technology according to the sample characteristics of nuclear pore complexes.
Fig.
On this basis, with the help of AlphaFold2, the most accurate protein three-dimensional structure prediction software, the researchers predicted the full-length three-dimensional structures of all nucleoporins in the Xenopus nuclear pore complex, and based on the high-quality three-dimensional reconstruction results, for The density map of the outer ring of the nuclear pore complex was modeled and modified, and the most complete NPC outer ring structure model was obtained
Researcher Sun Fei from the Institute of Biophysics, Chinese Academy of Sciences and Prof.
Article link: https://link.
(Contributed by: Fei Fei Research Group)
