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The latest paper from Sichuan University: Genetic and evolutionary mechanisms affecting the retention of introgression signals in poplar genome hybridization
Time of Update: 2022-01-24
Recently, Professor Wang Jing 's group from the School of Life Sciences of Sichuan University published a research paper entitled Demographic history and natural selection shape patterns of deleterious mutation load and barriers to introgression across Populus genome in the journal Molecular Biology and Evolution .
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"Cell" David Liu's team reports a new tool for in vivo gene editing - the first therapeutic-level virus-like particle!
Time of Update: 2022-01-24
Now, researchers led by a team at the Broad Institute of MIT and Harvard have developed a method to obtain gene-editing proteins inside cells in animal models with high enough efficiency to show therapeutic effects effect .
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Unexpectedly, "fat" is actually good for improving type 2 diabetes
Time of Update: 2022-01-24
By studying the cellular mechanisms at work, the researchers discovered how the cycle of fat storage and mobilization allows cells to adapt to excess sugar .
Thanks to these released fat molecules, cells adapt to the excess sugar, maintaining near-normal insulin secretion .
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First genome-wide de-novo mutational analysis of a family with obsessive-compulsive disorder
Time of Update: 2022-01-24
By sequencing the genomic DNA of 53 unrelated parent-child families, the researchers found that a subset of de novo mutations related to the regulation of chromatin modifications play an important role in OCD risk factors .
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"Nature" sub-issue: Surprised!
Time of Update: 2022-01-24
Using a technique called optogenetics, the scientists were able to switch neuropodocytes on and off in the guts of living mice to show whether the animals' preference for real sugar was driven by gut signals .
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Anti-GD2 and CD47 blockade mediate tumor eradication
Time of Update: 2022-01-24
This work demonstrates anti-gd2 and anti-CD47 binding for clinical translation and shows that CD47 blockade would be most effective in combination with monoclonal antibodies that alter additional pro- and anti-phagocytic signals in the tumor microenvironment .
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First Guinness World Record: Fastest Affordable DNA Sequencing Technology
Time of Update: 2022-01-24
The study was published in the New England Journal of MedicineFastest DNA sequencing technology could help undiagnosed patients find answers in just a few hoursScientists at Stanford School of Medicine and their collaborators have developed a new ultra-fast genome-sequencing method for diagnosing rare genetic diseases in an average of eight hours, a feat almost unheard of in standard clinical care .
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Zhao Shanchao's team published a high-level research paper in "Molecular Cancer"
Time of Update: 2022-01-24
Recently, the research team of Zhao Shanchao from Department of Urology, Department of Urology of Nanfang Hospital/Third Affiliated Hospital of our school published a research paper "Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p" in the internationally renowned journal "Molecular Cancer" .
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Change the electrical properties of tumors and reduce breast cancer metastasis!
Time of Update: 2022-01-24
Now, researchers at Tufts University have found that controlling the voltage patterns of tumor cells using an ion channel blocker, a drug already approved by the FDA to treat other diseases, can actually significantly reduce tumor cell invasion in a petri dish and metastasis in animal models of breast cancer .
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Researchers report brain-based approach to determining marijuana intoxication damage
Time of Update: 2022-01-24
Researchers at Massachusetts General Hospital (MGH) have found that a non-invasive brain imaging procedure is an objectively reliable way to identify those whose performance is impaired by THC, the psychoactive component in marijuana.
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How Triclosan, Found in Many Consumer Products, Triggers Gut Damage
Time of Update: 2022-01-24
"By identifying the culprit bacteria, new ways of diagnosing, preventing and treating inflammatory bowel disease could be developed," said study author Matthew Redinbo, chemistry and chemist at UNC-Chapel Hill College of Arts and Sciences and UNC School of Medicine.
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"A licorice MYB1 gene, its encoded protein and application" won the invention patent
Time of Update: 2022-01-24
It was learned on January 13 that "a licorice MYB1 gene, its encoded protein and application" completed by Wang Ying, Li Yongqing and other researchers of the South China Botanical Garden of the Chi
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Innovative anti-cancer therapy using red blood cells to extensively stimulate the immune system enters the clinic
Time of Update: 2022-01-24
On January 13, 2022, Rubius Therapeutics announced that it has completed the first patient dosing in a Phase 1/2 clinical trial of its red blood cell therapy RTX-224, designed to broadly stimulate the immune system, for the treatment of certain relapsed/refractory Patients with sexually advanced or locally advanced solid tumors, including non-small cell lung cancer, cutaneous melanoma, head and neck squamous cell carcinoma, urothelial (bladder) cancer, and triple-negative breast cancer .
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The Omicron virus can stay in this environment for 20 minutes!
Time of Update: 2022-01-24
Why is Omicron so contagious?A report published by Reuters today revealed one reason for the widespread spread of the Omicron variant: a very high rate of asymptomatic carriers .
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miRNA responsible for large size in human cerebral cortex
Time of Update: 2022-01-24
Borrell's team in the mouse embryonic cerebral cortex showed that expression of this microRNA alone is sufficient to promote the expansion of the brain's ventricular region, where neuron-producing stem cells are born .
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The keys to boosting your memory are right next to your pillow
Time of Update: 2022-01-24
"This is an exciting new finding about sleep because it tells us that the way in which information is reactivated during sleep to improve memory storage is associated with high-quality sleep," said Nathan Hui, lead author of the study.
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T-cell signatures associated with immune checkpoint blockade toxicity in melanoma patients
Time of Update: 2022-01-24
In this study, we used time-of-flight, single-cell RNA-sequencing, single-cell V(D)J-sequencing, bulk RNA-sequencing, and bulk T-cell receptor (TCR)-sequencing to assess patients receiving anti-PD-1 monotherapy or Peripheral blood samples from melanoma patients treated with anti-PD-1 and anti-CTLA-4 in combination with ICIs were studied .
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A new study provides a new therapeutic target for the treatment of sepsis
Time of Update: 2022-01-24
Image: The study also demonstrates that a drug originally developed to treat alcohol dependence can inhibit the activity of the molecule, preventing complications In an article published in the journal Blood, USP researchers and their collaborators propose a new strategy to prevent complications of sepsis .
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"Nature" challenges evolutionary DNA mutation theory!
Time of Update: 2022-01-24
"We've always thought of genetic mutations as basically random," said Grey Monroe, an assistant professor in the UC Davis Department of Plant Sciences and lead author of the paper .
"The plant has evolved a way to protect its most important places from mutation," Weigel said .
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Cell Metabolism: Metabolic vulnerability may be a new target for metastatic breast cancer
Time of Update: 2022-01-24
Metabolic differences may explain why some metastatic breast cancer cells rapidly develop tumors after they transfer from a primary tumor to the brain, while others develop these secondary The tumor lingers for months or years .
