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Zhao Shanchao's team published a high-level research paper in "Molecular Cancer"

 Last Update: 2022-01-24
 Source: Internet
 Author: User

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Recently, the research team of Zhao Shanchao from Department of Urology, Department of Urology of Nanfang Hospital/Third Affiliated Hospital of our school published a research paper "Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p" in the internationally renowned journal "Molecular Cancer"
.
Doctoral student Yu Yuzhong is the first author, and Zhao Shanchao is the last corresponding author

In this study, differentially expressed circRNAs were identified by RNA sequencing of prostate cancer clinical samples and found that hsa_circ_0003258 expression was increased in prostate cancer tissues and correlated with advanced TNM stage and ISUP grade
.
hsa_circ_0003258 is able to promote prostate cancer cell metastasis in vitro and in vivo by inducing epithelial-mesenchymal transition (EMT)

In conclusion, this study found that the up-regulation of hsa_circ_0003258 drives tumor metastasis through two pathways, the hsa_circ_0003258/miR-653-5p/ARHGAP5 axis and the hsa_circ_0003258/IGF2BP3/HDAC4 axis
.
This provides new potential biomarkers for metastatic risk prediction in prostate cancer and new potential targets for therapy

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