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Researchers from the University of Rochester and others published a research paper titled " Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm " in the Journal of the American Heart Association
.
The study showed that sildenafil (commonly known as Viagra), a drug used to treat pulmonary hypertension and erectile dysfunction, worsened abdominal aortic aneurysms
.
Sildenafil, commonly known as "Viagra", was developed by the American company Pfizer
.
It was initially used in clinical studies as a 5-phosphodiesterase (PDE5) inhibitor for the treatment of cardiovascular disease
.
However, it fell short of the researchers' expectations for dilating blood vessels and reducing cardiovascular disease
.
In April 1991, the clinical study of sildenafil officially failed
When surveyed, the volunteers said the drug had improved their sex lives
.
After that, the researchers at Pfizer changed their research direction and studied the effect of sildenafil on cavernosal smooth muscle
.
In 1998, sildenafil was approved by the FDA for the treatment of erectile dysfunction (ED) in men, which also made Pfizer famous
.
The aorta is composed of three layers, the middle layer is composed of vascular smooth muscle cells
.
These cells are responsible for regulating blood vessel tension, constricting and relaxing the aorta, thereby regulating blood flow
When the aorta does not regulate blood flow properly, the risk of developing an aortic aneurysm increases
.
5-phosphodiesterase (PDE5) is an important enzyme in the body, which has the ability to regulate the contraction of vascular smooth muscle cells
Previous clinical reports have demonstrated aortic dissection in some patients treated with PDE5 inhibitor drugs such as sildenafil
.
This suggests that inhibition of PDE5 may be associated with aortic risk
An abdominal aortic aneurysm is a portion of the abdominal aorta that becomes weak or bulged for a variety of reasons
.
A ruptured abdominal aortic aneurysm is an emergency
Once this happens, only 20% of patients survive
.
Abdominal aortic aneurysms are more common in older men, especially those with emphysema, a family history of abdominal aortic aneurysm, high blood pressure, high cholesterol, smoking, and obesity
.
Older men are the main user group of sildenafil
.
Therefore, the research team wanted to investigate whether inhibition of PDE5 by sildenafil affects the progression of abdominal aortic aneurysms
The research team conducted experiments on mice
.
The research team first surgically induced abdominal aortic aneurysms in mice and monitored the size of their aortas
Seven days after surgery, these mice developed abdominal aortic aneurysms
.
The mice were then randomly divided into two groups
The whole experiment lasted for 4 weeks, and the changes in the size of abdominal aortic aneurysms of the two groups of mice were observed
.
The experimental results showed that compared with mice that did not receive sildenafil, the abdominal aortic aneurysms in mice that received sildenafil for 4 weeks were larger, with an average width increase of 37%; elastic fibers in abdominal aortic aneurysms degenerated or Weakening has been increased by 50%
.
It is suggested that sildenafil can aggravate the progression of abdominal aortic aneurysm, which may be caused by interfering with the contraction and normal working ability of smooth muscle cells
.
Abdominal aortic aneurysms are more common in older men, with a high degree of overlap with major users of sildenafil
.
This study recommends that sildenafil be used with caution in patients with abdominal aortic aneurysm or in high-risk groups
.
The research team also said that further research is needed to determine that human use also carries this risk
.
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