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One study found that environmental stress, and lack of sleep, can significantly increase levels of2A (5-HT 2A ) neurotransmitter receptors
"Our study shows that environmental stimuli have the potential to alter the levels of receptors that play important roles in the brain within hours,
signaling mechanism
The role of the 5-HT2A receptor in controlling the human ability to understand and process information has been extensively studied
Receptor proteins on the surface of brain cells control communication networks within the brain
The 5-HT2A receptor receives encoded instructions from the HTR2A gene
The function of EGR3 is to bind to DNA and turn other genes on and off
effects on schizophrenia
The results of this study enhance our understanding of how the environment alters the expression of brain receptors that regulate function in the prefrontal cortex
Schizophrenia is a mental illness characterized by abnormalities in perception, thinking, and memory
Drugs that trigger a physiological response by binding to the 5-HT2A receptor are seeing a resurgence in the search for ways to treat symptoms of severe mental illness
"We wanted to understand how genes behave in response to environmental stimuli and how gene-environment interactions influence behavioral changes that can lead to psychiatric symptoms," Garitano said
This research was supported by NIH grants R01 MH097803 and R21 MHh113154-01a1 awarded to Galitano
Journal Reference :
Xiuli Zhao, Annika B.
