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1.
Research background
2.
Molecular mechanism of YTHDF3 regulating hematopoietic stem cell remodeling ability
Figure 1 Knockout of Ythdf3 reduces the remodeling ability of HSCs
Figure 2 Knockout of Ythdf3 results in decreased expression of CCND1 protein
Figure 3 YTHDF3 interacts with PABPC1 and eIF4G2 and promotes its translation by targeting the m6A modification site of Ccnd1 mRNA
Figure 4 Overexpression of CCND1 completely rescues the phenotype with reduced reconstitution capacity due to deletion of Ythdf3
Figure 5 METTL3 regulates CCND1 translation by promoting Ccnd1 RNA m6A modification
Figure 6 Deletion of Mettl3 results in a significant reduction in HSC reconstitution, and overexpression of CCND1 partially rescues the phenotype of reduced HSC reconstitution due to deletion of Mettl3
3.
Summary
Figure 7 The functional pattern of METTL3→RNA m6A→YTHDF3→CCND1 signaling pathway regulating HSC remodeling
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