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Pfizer plans to restart Phase 3 clinical trial of DMD gene therapy!
Time of Update: 2022-03-08
CompilenewbornIn December, Pfizer announced that a patient died in a bedridden cohort of a Phase Ib clinical trial evaluating the experimental gene therapy PF-06939926 in Duchenne muscular dystrophy (DMD) .
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Nature's 'mutation hotspot' map of 30 cancers
Time of Update: 2022-03-08
Can they tell us how cancer develops?"Erik Bergstrom, a bioengineering doctoral student in Alexandrov's lab and first author of the study, said: "Clustering mutations have been largely ignored because they represent a very small fraction of all mutations .
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Zhu Bing's research group and Xu Ruiming's research group cooperated to reveal that the CpG island-binding protein BEND3 regulates two processes in the differentiation process...
Time of Update: 2022-03-08
On February 10, 2022, Zhu Bing's research group from the Institute of Biophysics, Chinese Academy of Sciences, in cooperation with Xu Ruiming's research group, published a research paper titled "Highly enriched BEND3 prevents the premature activation of bivalent genes during differentiation" online in the journal Science .
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Human caloric restriction reveals immune-metabolic regulators of health-span
Time of Update: 2022-03-08
Expression of platelet-activating factor acetylhydrolase gene (PLA2G7) Human calories are decreasing .
In mice, deletion of PLA2G7 showed reduced thymic lipoatrophy, protection from age-related inflammation, decreased NLRP3 inflammasome activation, and improved metabolic health .
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Du Weiguo's team reveals the latitudinal pattern and mechanism of lizard energy metabolism in response to temperature domestication
Time of Update: 2022-03-08
Through comparative analysis, the researchers predict that (1) this temperature-responsive pattern of energy metabolism in temperate lizards may be universally applicable in ectothermic animals; (2) tropical species that lack domestication response will be more vulnerable in the context of climate warming and should be Focused and protected .
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Japan suspends sale of sea fish with excessive radiation
Time of Update: 2022-03-08
The Japanese government's Atomic Energy Disaster Response Headquarters instructed Fukushima Prefecture on the 8th to suspend the listing and sale of scorpion fish caught in the offshore waters of Fukushima Prefecture in accordance with the country's "Atomic Energy Disaster Response Special Measures Act" .
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How do pathogens learn to be pathogens?
Time of Update: 2022-03-08
They hope that by better understanding the ecology and survival strategies that Rhizopus and other pathogens use in normal environments, we will be better prepared to fight these microbes when they cause disease in humans .
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AI-assisted development of protein degraders Merck and CelerisTx reached R&D cooperation
Time of Update: 2022-03-08
On February 9, 2022, CelerisTx announced a research collaboration agreement with Merck KGaA, Germany, to use CelerisTx's graph-based artificial intelligence (AI) technology platform to discover and design novel small molecule binders and bifunctional protein degradation agent .
Retrieved February 9, 2022, from https:// menlo-park-ca-february-9-2022-celeristx-in-artificial-intelligence-research-collaboration-with-merck-kgaa-darmstadt-germany-on-ai-enabled-degrader-discovery/[3] Merck KGaA enlists little AI player on protein degrader discovery.
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The team of Professor Xia Ningshao of our hospital constructed a new live chickenpox vaccine with skin and nerve double attenuation properties
Time of Update: 2022-03-08
This study provides an important basis for clinical trials of VZV-7D as a new attenuated varicella vaccine .
Potential safety and efficacy of skin and nerve double attenuated varicella vaccine VZV-7DRecently, the research results were published online in Nature Communications in a paper entitled "Development of a skin-and neuro-attenuated live vaccine for varicella " .
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'Star-shaped' cells in the brain show unique activity patterns
Time of Update: 2022-03-08
Their findings, including patterns of signaling activity that correspond to the ultrafast signals seen in neurons and different behaviors, suggest that astrocytes may play a key role in many functions of our brain, including how we think, move and learn .
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The research group of Xia Lunguo/Fang Bing of the Ninth Affiliated Hospital published new achievements in the promotion of jaw regeneration and repair by nano-biomaterials-mediated immune regulation in ACS Nano
Time of Update: 2022-03-08
Among them, Associate Professor Xia Renguo/Professor Fang Bing from the Department of Orthodontics of the Affiliated Ninth People's Hospital, Professor Duan Shengzhong from the National Clinical Research Center for Oral Diseases, and Associate Professor Li Yulin from East China University of Science and Technology are the co-corresponding authors of the paper.
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Ji Guangju's group reveals the important role and mechanism of CUGBP1 in mouse myocardial regeneration
Time of Update: 2022-03-08
On February 8, 2022, Ji Guangju's research group from the Institute of Biophysics, Chinese Academy of Sciences published the research results online entitled "CUGBP1, a crucial factor for heart regeneration in mice" in " Cell Death & Disease " .
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Researchers identify brain region linked to satiety
Time of Update: 2022-03-08
A new University of Arizona-led study published in the journal Molecular Metabolism has uncovered a brain region and neural circuit that regulates satiety, which could help scientists better target drugs for eating disorders or weight management .
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"PNAS" New Perspectives on Cancer Metastasis Research
Time of Update: 2022-03-08
Kshitiz, assistant professor in the Department of Biomedical Engineering, discovered regulatory sequences in the genomes of mammals, including cows, pigs, horses, and humans, that explain how the endometrium is invaded by the placenta, and how normal How tissue is invaded by cancer .
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Li Wei's research group has made new progress in the clinical translational research of long-acting drug delivery preparations
Time of Update: 2022-03-08
Mark Prausnitz of Georgia Institute of Technology, USA , published an online publication titled " Clinical translation of long-acting drug delivery formulations ( DOI : 10.
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Nature Biotechnology Wei Wensheng's group reported an upgraded version of RNA editing technology: LEAPER 2.0
Time of Update: 2022-03-08
On February 10, 2022, Peking University Wei Wensheng's group published a long research paper on Engineered circular ADAR-recruiting RNAs increase the efficiency and fidelity of RNA editing in vitro and in vivo in the journal Nature Biotechnology .
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USTC has made important progress in tumor tissue microscopic magnetic imaging technology
Time of Update: 2022-03-08
, in cooperation with Professor Wei Haiming from the Department of Life Science and Medicine, have made important progress in the biomedical application of diamond nitrogen-vacancy color center quantum precision measurement technology, and established the first tumor Tissue immunomagnetic microscopy imaging technology realizes magnetic imaging with micron resolution at the tissue level, which has the advantages of high stability, low background and absolute quantification of tumor markers, and simultaneously realizes multimodal imaging of magnetic and optical .
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Associate Professor Zhang Xin's research group published an article in Computers in Human Behavior, proposing new strategies to reduce the elderly's fear of technology
Time of Update: 2022-03-08
Recently, Computers in Human Behavior published an article by Associate Professor Zhang Xin's research group When less intergenerational closeness helps: The influence of intergenerational physical proximity and technology attributes on technophobia among older adults .
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CD97 promotes splenic dendritic cell homeostasis through mechanosensing of erythrocytes
Time of Update: 2022-03-08
CD97 signaling enables cDC2s to localize at the tissue-blood interface, a location that optimizes antigen capture and mounts a rapid immune response to systemic pathogens .
We found that type 2 conventional DCs (cDC2s) of the spleen are Gα-dependent13and adhesion G protein-coupled receptor family member-E5 (Adgre5, or CD97) localizes to blood-exposed sites .
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Zhou Bin's group collaborated to reveal a new mechanism of coronary angiogenesis in mammalian neonatal hearts
Time of Update: 2022-03-08
TRS_Editor A{font-family:;font-size:12pt;}</> On February 4th, the international academic journal Circulation Research published the latest research titled "Extension of Endocardium-derived Vessels Generate Coronary Arteries in Neonates" by Zhou Bin's research group of the Center for Excellence in Molecular and Cell Science, Chinese Academy of Sciences and Luo Qingming's research group of Hainan University as a cover article.
