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The team of Professor Xia Ningshao of our hospital constructed a new live chickenpox vaccine with skin and nerve double attenuation properties

 Last Update: 2022-03-08
 Source: Internet
 Author: User

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Chickenpox is a highly contagious common skin disease of children caused by primary infection with the varicella - zoster virus ( VZV ) .

In this study, the researchers constructed the VZV Oka strain VZV-7D that lacks the expression of the virulence factor ORF7 , and applied a variety of in vitro and in vivo infection models, including human skin and nerve cell in vitro models, human skin / nerve tissue chimeric mice model, guinea pig model, cotton rat model, and primate model, systematically verified that the attenuated phenotype of VZV-7D in skin and nerve tissue can avoid the potential harm of varicella and herpes zoster after long-term latent reactivation.

Potential safety and efficacy of skin and nerve double attenuated varicella vaccine VZV-7D

Recently, the research results were published online in Nature Communications in a paper entitled "Development of a skin-and neuro-attenuated live vaccine for varicella " .

Paper link: https://

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