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CD97 promotes splenic dendritic cell homeostasis through mechanosensing of erythrocytes

 Last Update: 2022-03-08
 Source: Internet
 Author: User

CD97 helps DCs fight the flow

A subpopulation of traditional dendritic cells (dc) called cDC2s was found in the blood-exposed area of the spleen

These cells efficiently capture antigens from the blood and present them to T cells

These reactions usually occur in secondary lymphoid organs

₁₃-Containing heterotrimeric G-proteins can induce chemical exclusion, thereby helping to confine cells to tissue niches

₁₃The downstream effector ArhGEF1 is an essential factor for the localization of cDC2 in exposed areas of the mouse spleen

Gene set enrichment analysis indicated that the altered gene expression profile was partly due to increased activity of the G-actin-repressed Mrtf transcription factor

⁺red blood cells

Mechanosensing of CD97CD55

⁺Red blood cells localize splenic cDC2s near the bloodstream

In cross-sectional view, B cell follicles (F) and T cell areas (T) highlight white pulp fibers separated from red pulp (RP) by cDC2 containing bridging channels (BC; dashed box).

Summary

Dendritic cells (dc) are key to initiating adaptive immune responses

However, the factors that control DC localization and homeostasis are not fully understood

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