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The microcosm bears a striking resemblance to our world
.
In the environment around us, microbes live in complex communities -- some friendly, some not so friendly
In soil, its predator is the amoeba ( Dictyostelium ), a single-celled microorganism that moves through the soil and devours Rhizopus for nutrients
.
Scientists from the Universities of Exeter and Birmingham have discovered that Rhizopus fights back against this predator by cooperating in a two-way manner with a bacterium called Ralstonia
Why is this important for human disease? Our immune cells are very much like predator amoebae: they seek out, engulf and destroy foreign microbes that enter our bodies, protecting us from infection
.
This means that Rhizopus and Ralstonia can use the same strategy to avoid predators in the soil and thus evade our own immune systems
This work shows that when its partnership with Ralstonia is disrupted, animals infected with Rhizopus can survive the devastating disease
.
They hope that by better understanding the ecology and survival strategies that Rhizopus and other pathogens use in normal environments, we will be better prepared to fight these microbes when they cause disease in humans
"This work is important because, although we have known for many years that fungi and bacteria interact in soil to affect plant disease, this is the first example of bacteria and fungi interacting to cause mucormycosis in humans
.
We hope this will help We develop better strategies to treat this devastating disease," said Dr.
Herbert Itabangi, Poppy CS Sephton-Clark, Diana P.