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Ji Guangju's group reveals the important role and mechanism of CUGBP1 in mouse myocardial regeneration

 Last Update: 2022-03-08
 Source: Internet
 Author: User

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The cardiomyocytes of the mouse heart have continuous proliferation ability in the early postnatal period, and the heart damage at this time can realize self-regeneration and repair

On February 8, 2022, Ji Guangju's research group from the Institute of Biophysics, Chinese Academy of Sciences published the research results online entitled "CUGBP1, a crucial factor for heart regeneration in mice" in " Cell Death & Disease

In conclusion, this study systematically elucidated the role and mechanism of CUGBP1 in myocardial repair after injury, that is, CUGBP1 can promote myocardial cell proliferation and repair the heart after injury

Figure: CUGBP1 directly binds Wif1 and Sfrp5 to activate Wnt/β-catenin signaling to promote cardiac regeneration

Researcher Ji Guangju and Associate Researcher Wang Huiwen of the Institute of Biophysics, Chinese Academy of Sciences are the co-corresponding authors of the paper

Article link: https://pubmed.

(Contributed by Ji Guangju Research Group)

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