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Most patients with coronary artery disease lose their labor force, and the disability rate of myocardial infarction reaches 50%, which seriously endangers people's life and health
Coronary vessels originating from venous sinuses, defined as the first group of coronary vessels (1 st CVP), are mainly distributed in the lateral myocardial wall of the heart
During embryonic stage, endothelial cells of 1st CVP can migrate, fuse, and differentiate into coronary arteries
Imaging of the intact heart at the single-cell level
After the endocardium-specific Mettl3 knockout, more coronary arteries appeared in the heart; on the basis of Mettl3 knockout, the Notch signaling pathway Dll4 or Rbpj gene was knocked out, and the coronary artery formation in the heart was significantly reduced, suggesting that Mettl3-Notch signaling The pathway regulates the production of coronary arteries of endocardial origin
Researcher Zhou Bin from the Center of Excellence for Molecular Cells and Professor Luo Qingming from Hainan University are the co-corresponding authors of the paper
The incidence of coronary artery disease has been on the rise in recent years, and now it has become the number one killer of human health
.
Most patients with coronary artery disease lose their labor force, and the disability rate of myocardial infarction reaches 50%, which seriously endangers people's life and health
It is currently believed that the coronary endothelial cells of the developing heart are mainly derived from the venous sinus and endocardium
.
Coronary vessels originating from venous sinuses, defined as the first group of coronary vessels (1 st CVP), are mainly distributed in the lateral myocardial wall of the heart
Previous related studies believed that coronary arteries were mainly formed by scattered endothelial cells through angiogenesis, migration, aggregation, and remodeling
.
During embryonic stage, endothelial cells of 1st CVP can migrate, fuse, and differentiate into coronary arteries
In order to further elucidate the process of coronary artery formation by the migration and formation of endocardial-derived endothelial cells to the lateral myocardium, the researchers used fluorescence microscopic optical sectioning tomography (fMOST) method to conduct a more detailed analysis of the arterial formation process.
Imaging of the intact heart at the single-cell level
In terms of molecular mechanism, the researchers used a series of genetic methods of tissue-specific gene knockout to elucidate that the Mettl3 and Notch signaling pathways can regulate the formation of precursor coronary cords, thereby regulating this group of special coronary arteries in the developing heart.
quantity
.
After the endocardium-specific Mettl3 knockout, more coronary arteries appeared in the heart; on the basis of Mettl3 knockout, the Notch signaling pathway Dll4 or Rbpj gene was knocked out, and the coronary artery formation in the heart was significantly reduced, suggesting that Mettl3-Notch signaling The pathway regulates the production of coronary arteries of endocardial origin
Dr.
Tang Juan (now a researcher at Tongji University), PhD students Zhu Huan and Dr.
Tian Xueying (now a researcher at Jinan University) from the Center of Excellence for Molecular Cells are the co-first authors of the paper
.
Researcher Zhou Bin from the Center of Excellence for Molecular Cells and Professor Luo Qingming from Hainan University are the co-corresponding authors of the paper
Article link: https://
Circulation Research cover: Fluorescence images of the heart of Tie2-Cre;Cx40-LSL-GFP transgenic mice on day 7 of the neonatal period , where the green fluorescence signal represents coronary endothelial cells
