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Huazhong University of Science and Technology Cell Rep reports that cholecystokinin signaling regulates instinctual escape behavior

 Last Update: 2022-03-08
 Source: Internet
 Author: User

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On February 8, 2022, Beijing time, Gao Shangbang's research group from Huazhong University of Science and Technology published a research paper titled "Escape Steering by Cholecystokinin Peptidergic Signaling" in the journal Cell Reports, discovering the cholecystokinin receptor signaling that regulates satiety Important role in instinctual avoidance behavior
.

In this study, the rapid retreat, turning, and re-advance sequence of nematodes exhibited by strong noxious stimuli was used as the experimental paradigm.
The robust steering movement requires activation of the cholecystokinin signaling pathway
.

The neuropeptide NLP-18 required for steering regulation is released by taste receptor neurons ASI, activating the cholecystokinin-like receptor CKR-1 on downstream head motor neurons SMD and interneurons AIB

Fig 1.
Neural circuit and neuropeptide molecular mechanism of instinctual escape behavior regulation

This work reveals that the neuromodulatory (neuropeptide) signaling pathway, known for its slow release and slow response over time, also plays a key role in fast escape behavior, providing insights into neural circuits and molecular regulation mechanisms of intrinsic instinctive behavior new ideas
.

Huazhong University of Science and Technology doctoral students Chen Lili and Liu Yuting are the co-first authors of the paper
.

Professor Gao Shangbang, School of Life Science and Technology, Huazhong University of Science and Technology is the corresponding author of the paper

About the corresponding author
Gao Shangbang, Ph.

(http://faculty.

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