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A novel transcription initiation checkpoint--molecular mechanism by which RPAP2 negatively regulates transcription initiation
Time of Update: 2022-05-12
On April 26 , 2022 , the team of Fudan University Chen Xizi, Xu Yanhui and Chen Fei collaborated in Cell ReportsThe journal publishes a research paper titled " RPAP2 regulates a transcription initiation checkpoint by inhibiting assembly of pre-initiation complex" online .
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Nature sub-journal: 7 hours is the best sleep time for middle-aged and elderly people
Time of Update: 2022-05-12
Seven hours of sleep is the ideal sleep time for middle-aged and middle-aged adults, with too little or too little sleep leading to cognitive decline and worsening mental health, according to researchers from the University of Cambridge and Fudan University .
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Liu Zhibo's group reported a new type of boron-containing liposome (Boronsome) for adjuvant chemotherapy..
Time of Update: 2022-05-12
Recently, Liu Zhibo's group from the Center for Life published a research paper entitled "Boron encapsulated in a liposome can be used for combinational neutron capture therapy" in Nature Communications( DOI : https://doi.
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Qian Feng's research group from the School of Pharmacy, Tsinghua University has made a series of new progress in the development of mAb aggregation kinetics, solution stability mechanism and application and development of high-concentration mAb preparations
Time of Update: 2022-05-12
1 nucleation growth onsetFigure 1: Kinetic process of phase separation of monoclonal antibody solution - nucleation and growth .
3Figure 3: The technical implementation path of monoclonal antibody suspension: 1.
Select non-aqueous organic solvent to suspend monoclonal antibody particles to obtain high-concentration, low-viscosity suspension .
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The rapeseed team cooperated with the bioinformatics team to reveal the adaptive evolution mechanism of clubroot disease resistance genes
Time of Update: 2022-05-12
Nanhu News Network News (Correspondent Yang Zhiquan Jiang Yingfen) Recently, the research results of the research team of Professor Zhang Chunyu and Professor Yang Qingyong of the rapeseed team of our school and the team of Professor Park Zhongyun of Shenyang Agricultural University were published in Plant under the title "R gene triplication confers European fodder turnip with improved clubroot resistance".
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Angew. Chem. Int. Ed. Photocatalytic chemical crosslinking..
Time of Update: 2022-05-12
However, the authors also pointed out that the induction of reactive oxygen species will inevitably cause damage to cells, so the authors hope to develop RNA-protein cross-linking methods with higher biocompatibility or more rapid response in the follow-up research .
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Lei Xiaoguang's research group, Tang Chun's research group and collaborators have developed a new generation of chemical cross-linking mass spectrometry technology in the School of Chemistry
Time of Update: 2022-05-12
9" >The research group of Professor Lei Xiaoguang and Professor Tang Chun of the School of Chemistry and Molecular Engineering of Peking University cooperated with the research group of Professor Dong Mengqiu of the Beijing Institute of Biological Sciences to publish a collaborative paper in the journal Nature Communications with the title " Characterization of protein unfolding by fast cross- linking mass spectrometry using di-ortho-phthalaldehyde cross-linkers ” .
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The regulatory role of SRSF2 in skeletal muscle embryonic development
Time of Update: 2022-05-12
On April 23, 2022, the international academic journal Advanced Science published a collaboration titled "Single-Cell RNA Sequencing Reveals Heterogeneity of Myf5-Derived Cells and Altered Myogenic Fate in the The latest research results of Absence of SRSF2" .
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Novel "SwissKASH" tool visualizes palmitoylation in living cells
Time of Update: 2022-05-12
More specifically, the enzymes studied in this method, palmitoyl acyltransferases (PATs), catalyze lipid modifications that allow peripheral membrane proteins to temporarily bind to cell membranes .
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Peking University Nature Publishes Breakthrough Research Achievement: Artificial Intelligence Assists Time-Resolved Cryo-EM to Discover Dynamic Regulation Mechanisms of Major Drug Targets
Time of Update: 2022-05-12
Molecular machines of life achieve their special functions through highly complex non-equilibrium kinetic processes and structural changes, which are then precisely regulated by various complex interm
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Mao Youdong's team at Nature Life Center published breakthrough research results - artificial intelligence ..
Time of Update: 2022-05-12
Molecular machines of life achieve their special functions through highly complex non-equilibrium kinetic processes and structural changes, which are then precisely regulated by various complex inte
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Cell: Mechanism of action of GPCRs
Time of Update: 2022-05-12
"In our study, we used an approach that allowed us to explore, in unprecedented detail, how drug-stimulated GPCRs activate β-arrestin, a protein that both terminates some signals and mediates others ” said Wesley B.
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Fujian Agriculture and Forestry University publishes the latest research results in the top international academic journal "Science"
Time of Update: 2022-05-12
Recently, the research team of Fujian Agriculture and Forestry University Su Songkun led the team of Professor Martin Giurfa from the University of Toulouse III, France, and Professor Zhang Shaowu fro
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Gene editing technology completes the last piece of the puzzle
Time of Update: 2022-05-11
Researchers at the Center for Genome Engineering at the Korea Institute for Basic Science (IBS) have developed a new gene editing platform called Transcription Activator-Like Effect-Associated Deaminase (TALED) .
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New technology will revolutionize visualization of important biomolecules such as proteins
Time of Update: 2022-05-11
Shaopeng Wang is a research fellow at Arizona State University's Center for Bioelectronics and Biosensor Biodesign and the School of Biological and Health Systems Engineering .
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Discovery of biological pathways driving genomic alterations and bone metastasis in Ewing's sarcoma, a rare childhood cancer
Time of Update: 2022-05-11
The pathway the scientists discovered involves a receptor on the surface of cancer cells called Y5R, which plays a role in mediating the effects of hypoxia -- if it's blocked or turned off, genetic changes are limited, thereby suppressing tumors.
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Nearly half of brain cells have new function
Time of Update: 2022-05-11
A new function of astrocytes discovered in mice opens up a whole new direction for neuroscience research that could one day lead to treatments for everything from epilepsy to Alzheimer's to traumatic brain injury, scientists say methods of many diseases .
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Neural pathway identifies key to pleasurable touch
Time of Update: 2022-05-11
" Researchers at the University of Washington's Center for Itching and Sensory Disorders have discovered a specific neuropeptide and a neural circuit that transmits pleasant touch from the skin to the brain .
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A multidimensional gene regulatory network in the locust of legumes' motor organ
Time of Update: 2022-05-11
Research paper on Multidimensional Gene Regulatory Landscape of Motor Organ Pulvinus in the Model Legume Medicago truncatula In this study, the tissues of the wild-type lamina of Medicago truncatula and the corresponding parts of the elp1 mutant lamina were collected for comparative analysis of transcriptome and proteomics .
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Dong Jianfei's research group from Suzhou Institute of Medical Technology has made progress in dynamic process analysis and data-driven modeling of phototherapy
Time of Update: 2022-05-11
In order to analyze the kinetics of the photo-oxidative reaction in the phototherapy process and propose a simple and effective modeling method, Dong Jianfei's research group applied basic control theory to analyze the process, and obtained the linearization of the first-principles PDT model.
