 Home > Biochemistry News > Biotechnology News > Qian Feng's research group from the School of Pharmacy, Tsinghua University has made a series of new progress in the development of mAb aggregation kinetics, solution stability mechanism and application and development of high-concentration mAb preparations

Qian Feng's research group from the School of Pharmacy, Tsinghua University has made a series of new progress in the development of mAb aggregation kinetics, solution stability mechanism and application and development of high-concentration mAb preparations

 Last Update: 2022-05-12
 Source: Internet
 Author: User

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1 3 dichloropropene

2 solution

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Figure 1: Kinetic process of phase separation of monoclonal antibody solution - nucleation and growth
.

Figure 2: Electrostatic interactions induce the formation of ATP-mAb complexes, which in turn alter the colloidal behavior of the solution
.

Figure 3: The technical implementation path of monoclonal antibody suspension: 1.
Use spray drying technology to prepare stable monoclonal antibody solid particles; 2.
Select non-aqueous organic solvent to suspend monoclonal antibody particles to obtain high-concentration, low-viscosity suspension
.

1.
Int J Pharm 2020

2.
Mol Pharm 2021

3.
Mol Pharm 2022

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