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Can lipid 'SPMs' suppress inflammation?
Time of Update: 2022-05-08
But what if much of the research on SPMs is based on flawed science?In a paper published last month in Frontiers in Pharmacology, an international group of 18 scientists, including experts in lipid analysis, argued that studies that identify these molecules in the human body often detect them at very high levels.
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Nature: New approach to 'regain' hearing cells lost during aging
Time of Update: 2022-05-08
But Northwestern Medicine scientists have identified a single master gene that remodels ear hair cells into either outer or inner cells, overcoming a major hurdle that prevents these cells from developing to restore hearing .
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Gene Expression in the Nervous System: Targeted Stimulation Mechanisms Discovered
Time of Update: 2022-05-08
"For the first time, we have successfully demonstrated a direct mechanistic link between enhancer RNAs and the transcriptional process controlled by Pol II, a key component of gene expression," said Dr.
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Nature opens up new food: fungus-based meat substitute
Time of Update: 2022-05-08
""In the future, replacing ruminant meat with microbial proteins could significantly reduce the greenhouse gas footprint of the food system," the authors said .
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Study reveals how blood vessels use 'shortcuts' to control cardiovascular system
Time of Update: 2022-05-08
The findings suggest that the endothelial communication network is designed to be similar to the communication operation of the Internet, which can effectively control local blood vessels and improve overall efficiency in determining overall cardiovascular activity .
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New Cell study provides new insights into gene activity and addiction mechanisms
Time of Update: 2022-05-08
Researchers at North Carolina State University have demonstrated that neuron-like cells derived from human stem cells can serve as models for studying addiction-related changes in the nervous system .
"In their study, Tam and Keung exposed neuron-like cells derived from human stem cells to different levels of dopamine for different periods of time .
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Gene-edited brain 'factory reset' may cure anxiety and alcoholism
Time of Update: 2022-05-08
In previous research, the UIC team found that alcohol abuse during adolescence alters chemicals in the brain's boosted regions of the Arc gene -- an activity-regulated cytoskeleton-associated protein immediate early gene -- and reduces almond and almond growth in rodents and humans.
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How the Herpes Virus Awakened
Time of Update: 2022-05-08
How herpesviruses reactivate from dormancy is a central question in herpesvirus research, and a previously unknown key is a viral microRNA called miR-aU14 .
Interestingly, the Würzburg research group was also able to show that viral microRNAs are not only necessary for viral replication, but also directly trigger virus reactivation from a dormant state .
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BeiGene's Bispecific Antibody Therapy Approved in China to Treat Certain Childhood Leukemia
Time of Update: 2022-05-08
A few days ago, BeiGene announced that the National Medical Products Administration (NMPA) of China has approved Belito (Belintoumumab for injection, English trade name Blincyto) for the treatment of children with relapsed or refractory (R/R) CD19-positive precursor B-cell acute lymphoblastic leukemia (ALL) .
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Optogenetics may be overstated as a potential neurotherapeutic
Time of Update: 2022-05-08
They found that optogenetics had a 91 percent success rate in nonhuman primates based on measured changes in neural activity or observed behavioral changes .
When the researchers considered only "robust" results, they found that the technique worked in 76 percent of cases .
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Vegetarian diet aids weight loss, lowers blood sugar in adults with overweight or type 2 diabetes
Time of Update: 2022-05-08
In this study, researchers conducted a systematic review and meta-analysis of all relevant English-language randomized trials, to be published in March 2022, comparing the effects of a vegan diet to other types of diets on metabolic disease risk factors -- weight, body Mass Index (BMI), blood sugar levels, systolic and diastolic blood pressure, total cholesterol, LDL cholesterol (so-called "bad cholesterol"), HDL cholesterol and triglycerides .
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The first in-depth exploration of the anticancer activity of capsaicin sustained-release preparations
Time of Update: 2022-05-08
Tirona, MD, Joshua Hess, MD, and Paul Finch, MD, and co-authors Stephen Richbart, Justin Merritt, Ashley Cox, Emily moler, and Katie Brown also contributed to the publication contributed .
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New Evidence from Microbiome: Does Fecal Transplantation Really Reverse the Characteristics of Aging?
Time of Update: 2022-05-08
However, scientists from the Quadram Institute and the University of East Anglia have provided evidence, through studies in mice, that transplanting the fecal microbiota of young mice into older mice can reverse the ageing characteristics of the gut, eyes and brain .
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Nature's cell division study finds new cancer treatment
Time of Update: 2022-05-08
Researchers at Weill Cornell Medicine and Dana-Farber Cancer Institute report that a protein called CDC7 can actually be replaced by another protein called CDK1, which plays a role in cell division.
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Two innovative therapies for the treatment of autoimmune diseases reach phase 3 clinical endpoints
Time of Update: 2022-05-08
argenx announced that its antibody therapy Vyvgart (efgartigimod alfa-fcab) targeting the neonatal Fc receptor (FcRn) met the primary endpoint in a Phase 3 clinical trial for the treatment of immune thrombocytopenia (ITP), comparable to placebo The proportion of patients who achieved sustained platelet remission was significantly higher .
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How do sex hormones define the brain differences between men and women?
Time of Update: 2022-05-08
"Tollkuhn's team looked at the location of estrogen receptors after a hormonal surge, concentrated in a brain region called the bed nucleus of the stria terminalis, which is larger in males than females in mice and humans .
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The benefits of the PNAS movement can vary widely
Time of Update: 2022-05-08
In a new study, researchers at Children's Hospital of Philadelphia (CHOP) demonstrate that the benefits of endurance exercise may vary depending on the type of mutation involved in mitochondrial disease, and while the benefits of exercise outweigh the risks, exercise therapy should be recommended.
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Severe obesity impairs antibody response to COVID-19 vaccine, study shows
Time of Update: 2022-05-08
Among those who had not been infected with SARS-CoV-2 and had received the Pfizer/Biotech vaccine, severely obese patients had antibody levels more than three times lower than normal-weight controls (average 5823 vs 19371 AU/ml; note to editors) in Table 1) .
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The research paper on the broad-spectrum advantages of China Cell's bivalent new crown vaccine SCTV01C was officially published
Time of Update: 2022-05-08
Table 1 Neutralizing antibody titers of mouse sera against 14 main mutant strains after inoculation with 2 doses of monovalent vaccine (Alpha or Beta) or SCTV01CThe neutralizing antibody titers of the bivalent vaccine SCTV01C against different variants showed a significant broad-spectrum advantage .
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New findings from "PNAS" challenge common assumptions: "Speaking" has no so-called single control area
Time of Update: 2022-05-08
By carefully mapping the neural networks of marmosets and macaques, they determined that multiple areas of the frontal lobe of the brain control the muscles that produce vocalizations and may provide the basis for complex language .
