The benefits of the PNAS movement can vary widely

In a new study, researchers at Children's Hospital of Philadelphia (CHOP) demonstrate that the benefits of endurance exercise may vary depending on the type of mutation involved in mitochondrial disease, and while the benefits of exercise outweigh the risks, exercise therapy should be recommended.

Primary mitochondrial disease is the most common inherited metabolic disorder, affecting approximately 1 in 4,200 people

However, these recommendations are based on healthy people without primary mitochondrial disease

Patrick Schaefer, PhD, a postdoctoral researcher in the CHOP Center for Mitochondrial and Epigenomic Medicine and the study's first author, said: "Among clinicians who have seen patients with mitochondrial disease, there is no question as to whether endurance exercise is actually beneficial.

Because of the heterogeneity of primary mitochondrial disease among patients, the researchers used animal models to study the five mutations that cause the disease

The study found that the effects of endurance exercise on the model depended on the mutations involved

In addition, the researchers were able to correlate the gene expression profiles of skeletal muscle and heart in the model with exercise responses and identified oxidative phosphorylation, amino acid metabolism, and cell cycle regulation as key pathways in exercise responses

Although responses from the models used in this study were mixed, the authors noted that, in most cases, the benefits of exercise outweighed the risks

"This work is of fundamental importance and shows that individuals with different mitochondrial bioenergetics respond differently to endurance exercise,

1. Patrick M.

   
   

Children's Hospital of Philadelphia.

Children's Hospital of Philadelphia.

Children's Hospital of Philadelphia.