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To date, there are eight different herpesviruses known to humans
During evolution, most herpesviruses learned to use small RNA molecules, so-called microRNAs, to reprogram host cells in their favor
Problems after virus reactivation
More than 90% of people are infected with the HHV-6 virus without realizing it
Reactivation of HHV-6 is suspected to impair cardiac function, cause rejection of transplanted organs, and trigger diseases such as multiple sclerosis or chronic fatigue syndrome (ME/CFS)
How herpesviruses reactivate from dormancy is a central question in herpesvirus research, and a previously unknown key is a viral microRNA called miR-aU14
The role of microRNA in cells
The regulation of miR-aU14 comes from the virus itself
Through this pathway, viral miR-aU14 induces mitochondrial fragmentation
Thus, viral miR-aU14 interferes with the production of the type I interferon messenger substance through which cells signal the presence of the virus to the immune system
The researchers now want to understand the exact mechanism by which viral microRNAs activate the virus
This work from Würzburg shows for the first time that one microRNA can directly regulate the maturation process of other microRNAs
This article was provided by the University of Würzburg
