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Mao Youdong's team at Nature Life Center published breakthrough research results - artificial intelligence ..

 Last Update: 2022-05-12
 Source: Internet
 Author: User

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Molecular machines of life achieve their special functions through highly complex non-equilibrium kinetic processes and structural changes, which are then precisely regulated by various complex intermolecular interactions

Mao Youdong Laboratory of Peking University has long been committed to the development of cryo-electron microscopy-based kinetic reconstruction methods and their biomedical applications, focusing on the structure, function, kinetic mechanism and biomedical application of target systems with great clinical application prospects, such as proteasome and inflammasome.

Figure 1.

The process of scientific research is always full of ups and downs

The study found that the activation of USP14 is dependent on both ubiquitin recognition and the binding of the proteasome RPT1 subunit

Figure 2.

Zhang Shuwen, a postdoctoral fellow in the research group, and Zou Shitao, a 2019 doctoral student, are the co-first authors of the paper, and Mao Youdong is the corresponding author

Nature paper online link:

https://doi.

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