-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
In a study of mice transplanted with human Ewing's sarcoma tissue, researchers at Georgetown University Medical Center and colleagues identified a biological pathway that is disrupted when tissue is deprived of oxygen due to rapid tumor growth.
The pathway the scientists discovered involves a receptor on the surface of cancer cells called Y5R, which plays a role in mediating the effects of hypoxia -- if it's blocked or turned off, genetic changes are limited, thereby suppressing tumors.
The discovery was published in the journal Nature Communications on April 28, 2022
In the United States, approximately 200 children and young adults are diagnosed with Ewing's tumor each year
"While the role of rapid genetic changes in promoting cancer growth is well known, the mechanisms that trigger these changes are unknown, and strategies to prevent them are lacking,
The current standard of care for Ewing's sarcoma includes systemic cell-killing chemotherapy, which affects all cells in the body, causing side effects
There are currently many drugs targeting Y5R, as Y5R has also been implicated in the regulation of food intake and psychiatric disorders
Kitlinska said: "We will continue to conduct experiments in mice to try to determine the mechanism that triggers the spread of
Hypoxia-activated neuropeptide Y/Y5 receptor/RhoA pathway triggers chromosomal instability and bone metastasis in Ewing sarcoma
