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Researchers identify key regulator of urine concentration in kidney
Time of Update: 2022-05-13
His research group found that while AP-2β is required for renal function to survive by regulating the development and function of the distal convoluted tubule, AP-2α is an important intrinsic function of a distinct segment of the distal nephron, called the collecting duct, which is involved in The ability of the kidneys to concentrate urine .
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Yao Jing's research group reported the new progress of TRP channel research in PNAS
Time of Update: 2022-05-13
By investigating the East Asian pincer scorpion genome and transcriptome database successfully established by teachers such as Li Wenxin from the School of Life Sciences of Wuhan University, using the conserved domain of TRP channel protein, combined with genome screening and patch clamp electrophysiological experiments, the researchers cloned and identified for the first time a Transient receptor potential channel expressed in East Asian pincer scorpion, named sTRP1 .
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Liu Tiangang's research group achieves efficient discovery of terpenoid products from filamentous fungi
Time of Update: 2022-05-13
High-throughput mining of terpenoid biosynthetic gene clusters in filamentous fungi and efficient product synthesisTerpenoids are the most abundant natural products in nature.
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Non-toxic silver coating resists and kills bacteria
Time of Update: 2022-05-13
They report that the coating, which can be applied by a single-step dipping, spraying or solution peeling process, is non-toxic and enables sustained, long-term silver release from different types of surfaces and medical devices, preventing bacteria from adhering to these materials more than 30 days .
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Blocking or deleting a protein could help prevent common oral cancer
Time of Update: 2022-05-13
Bais, assistant professor of translational dentistry at Boston University's Goldman School of Dentistry, has identified the lysine-specific demethylase 1 protein as a potential "drugable target" for oral cancer, a finding that may have implications for A day will help doctors remove the tumor .
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Lignin-based jet fuel has more power, less pollution
Time of Update: 2022-05-12
An experimental plant-based jet fuel could improve engine performance and efficiency while eliminating aromatic hydrocarbons, the polluting compounds added to conventional fuels, according to a new study .
""The lignin-based fuels we tested complement other sustainable aviation fuels by increasing the density of the blend and, most importantly, ring expansion potential," Heyne said .
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New discovery: Causes of drug-induced Parkinson's disease
Time of Update: 2022-05-12
Recently, researchers from the Guangzhou Institutes of Biomedicine and Health (GIBH) of the Chinese Academy of Sciences and the Second Affiliated Hospital of Zhejiang University School of Medicine revealed that FNZ induces Parkinson's disease by stimulating the integration of mitochondria and lysosomes (called mitosomes) mechanism of disease .
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CRISPR validates lupus genetics from sensing RNA virus gene mutations
Time of Update: 2022-05-12
An international team of researchers has found that DNA mutations in a gene that senses viral RNA are responsible for the autoimmune disease lupus, a discovery that paves the way for the development of new treatments .
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"Space Fungus" broadens the innovation path of plateau characteristic edible fungus breeding
Time of Update: 2022-05-12
The research team of Yang Zhuliang, Kunming Institute of Botany, Chinese Academy of Sciences, relying on Yunnan's major scientific and technological special projects and key R&D plans - aerospace breeding and aerospace food R&D and demonstration aerospace breeding ( 202202AE090001 ) project, carried the white ginseng strain "to heaven" through Shenzhou No.
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Microbiologically revealed mechanism of super biofilm formation caused by small fragment deletion of Pseudomonas aeruginosa methylated chemotactic receptor protein WspA
Time of Update: 2022-05-12
In conclusion, this study revealed the mechanism by which the methylated chemotactic receptor protein WspA activates the synthesis of cyclic-di-GMP through the loss of small fragments , thereby leading to the formation of super biofilms in strains.
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Daiichi Sankyo/AstraZeneca's Enhertu receives FDA breakthrough therapy designation for breast cancer
Time of Update: 2022-05-12
On April 27, AstraZeneca and Daiichi Sankyo jointly announced that the HER2 ADC drug Enhertu has been granted Breakthrough Therapy Designation (BTD) by the FDA for relapse or progression within six months of adjuvant therapy after receiving at least one prior systemic therapy Patients with unresectable or metastatic breast cancer with low HER2 expression (IHC1+orIHC2+/ISH-negative) .
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Cell reprogramming improves liver regeneration in mice
Time of Update: 2022-05-12
Mako Yamamoto [Salk Institute]The authors previously showed that four cell-reprogramming molecules -- oct-3/4, Sox2, Klf4, and c-Myc, known as Yamanaka factors -- slowed the aging process in mice and improved muscle tissue regeneration .
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Ten years of sharpening a sword - a modern classification system of Chaetaceae fungi established by microorganisms
Time of Update: 2022-05-12
Through analysis and comparison, the research group first determined the best molecular markers to distinguish different genera and species within the family, and established a set of methods to observe and study different morphological structures such as ascomas, ascus, ascospores, and asexual reproduction structures ( as shown in Figure 1 , 2 ) .
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Wang Lu, a young researcher from the School of Pharmacy, has made progress in the field of super-resolution imaging fluorescent probes
Time of Update: 2022-05-12
The research project synergizes TICT action inhibition strategy and asymmetric dye strategy to simultaneously improve dye brightness, photostability, and Stokes shift for STED super-resolution fluorescence imaging .
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The rapeseed team cooperated with the bioinformatics team to reveal the adaptive evolution mechanism of clubroot disease resistance genes
Time of Update: 2022-05-12
Nanhu News Network News (Correspondent Yang Zhiquan Jiang Yingfen) Recently, the research results of the research team of Professor Zhang Chunyu and Professor Yang Qingyong of the rapeseed team of our school and the team of Professor Park Zhongyun of Shenyang Agricultural University were published in Plant under the title "R gene triplication confers European fodder turnip with improved clubroot resistance".
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The South China Botanical Garden has made important progress in the regulation of the flowering stage of Paphiopedilum
Time of Update: 2022-05-12
The research team of Zeng Songjun from the Agricultural and Biological Center of the South China Botanical Garden of the Chinese Academy of Sciences used the single-flowered Paphiopedilum callosum as the research material.
The possible mechanism of exogenous gibberellin regulating accessory flower development and bolting of Paphiopedilum callosum Figure 3.
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Research progress of Lin Xu's research group and China Kadoorie Biobank research team on the level of erythrocyte membrane polyunsaturated fatty acids and stroke risk in Chinese population
Time of Update: 2022-05-12
In this study, Associate Researcher Sun Liang from Lin Xu's research team collaborated with the CKB research team to systematically analyze the geographical distribution characteristics of various erythrocyte membrane PUFAs and their association with different subtypes of stroke (such as ischemic and hemorrhagic stroke).
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Reduced genetic diversity of immune system may affect survival of endangered toads
Time of Update: 2022-05-12
"The decline in the population of this species created a genetic bottleneck in the first place, which means the level of genetic diversity is already very small," said Jeff Yoder, a professor of comparative immunology at North Carolina State University and a co-author of the study.
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Angew. Chem. Int. Ed. Photocatalytic chemical crosslinking..
Time of Update: 2022-05-12
However, the authors also pointed out that the induction of reactive oxygen species will inevitably cause damage to cells, so the authors hope to develop RNA-protein cross-linking methods with higher biocompatibility or more rapid response in the follow-up research .
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Nature Cancer of Sichuan University: First elucidation of the molecular regulatory mechanism of epigenetic reprogramming of small cell lung cancer metastasis
Time of Update: 2022-05-12
On April 21, the team of Professor Chen Chong of the State Key Laboratory of Biotherapy and the team of the Department of Thoracic Oncology published a research paper "KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming" in Nature Cancer, which clarified for the first time histone methyl Deletion of the transferase KMT2C promotes an epigenetic mechanism of distant metastasis in small cell lung cancer (SCLC) through histone-DNA synergistic hypomethylation .
