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According to folklore, silver bullets can kill werewolves, but in fact, researchers have been looking to harness the metal to fight bacteria
Dr.
Implanted medical devices, such as tubes used to drain wounds or bladders, or tubes that deliver drugs directly into the bloodstream, can quickly become overrun by bacteria, creating a dangerous risk of infection
Researchers have been working to develop antibacterial coatings, including those that contain silver, which kills microorganisms
Silver also has toxic effects on human cells, for example, it is difficult to create a coating that releases small amounts of the metal consistently over a long period of time
Lange, Kizhakkedathu and colleagues wanted to find a silver-containing formula to overcome these and other difficulties
In in vivo tests, the team applied the SAFE coating to the surface of titanium implants, which were then placed under the skin of rats
The SAFE coating also appears tough, with little to no wear after being rubbed and sterilized in harsh conditions
Nonetheless, the researchers concluded: "In this work, we developed SAFE components that form silver coatings with long-term bacterial-free adhesion (>30 days) and no silver toxicity, both in vitro and in vivo.
