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The regenerative capacity of an organism depends on cellular dedifferentiation and subsequent proliferation
The work was published in Cell Reports in the paper "Partial cellular reprogramming enhances liver plasticity and regeneration in vivo
"We are excited to make progress in repairing damaged liver cells, because one day, such an approach could be extended to replace the entire organ itself," said Juan Juan, professor of Salk University's Gene Expression Laboratory and director of the Altos laboratory.
"Unlike most of our other organs, the liver is more efficient at repairing damaged tissue," said Mako Yamamoto, PhD, a postdoc in Izpishu Belmonte's lab
The question facing many researchers in the field is how to control the expression of factors needed to improve cell function and rejuvenation, as some of these molecules can lead to rampant cell growth, such as cancer
"The Yamanaka factor is really a double-edged sword," said Dr.
While studying this reprogramming mechanism in a lab dish, the scientists made a second discovery: A gene called Top2a, involved in reprogramming liver cells, was highly active in the day following short-term Yamanaka factor treatment
"There is still a lot of work to be done before we fully understand the molecular basis of how cells are programmed to regenerate," Izpisu Belmonte said
