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FDA Fast Track Designation for Innovative Cell Therapy for HPV16-Positive Solid Tumors

 Last Update: 2022-05-11
 Source: Internet
 Author: User

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Article source: Medical Cube Info

Author: Pickup

On April 27, SQZ Biotechnologies announced that the U.

Human papillomavirus (HPV) is one of the most common viruses in the world, and some strains can live in the body for many years, often causing cancer

SQZ-PBMC-HPV is based on the company's technology platform called "Cell Squeeze"

SQZ-PBMC-HPV is developed based on the company's SQZ® APCs platform, which induces a specific T cell response against the antigen by encapsulating the target antigen in APC cells

Data presented at the 2021 ESMO Immuno-Oncology Congress showed that SQZ-PBMC-HPV monotherapy induced radiographic, symptomatic, and immune responses in immune checkpoint PD-1-treated patients with HPV16-positive solid tumors

SQZ-PBMC-HPV is currently being evaluated in a Phase I/II clinical trial for the treatment of patients with HPV16+ advanced or metastatic solid tumors positive for human leukocyte antigen serotype HLA-A*02

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