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Next-Generation Anti-CTLA-4 mAb Receives FDA Fast Track Designation for the Treatment of Non-Small Cell Lung Cancer

 Last Update: 2022-05-11
 Source: Internet
 Author: User

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On April 26, OncoC4 announced that the U.

PD-1/L1 inhibitor-resistant non-small cell lung cancer is one of the clinical challenges of immunotherapy, and there is a huge unmet medical need

As a new generation of anti-CTLA-4 monoclonal antibody, ONC-392 can more effectively and selectively remove regulatory T cells in the tumor microenvironment, which is an important part of tumor immune escape The main "culprit"

Currently, ONC-392 is undergoing a Phase 1 clinical study overseas (PRESERVE-001 study) to evaluate its safety, pharmacokinetics, and efficacy as monotherapy and in combination with anti-PD-1 standard therapy in advanced solid tumors and NSCLC.

In China, OncorImmune is conducting a Phase 1 clinical study of ONC-392, which aims to evaluate the safety, tolerability and pharmacokinetics of the drug as a monotherapy for advanced solid tumors in the Chinese population

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