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Precious tears: Mass spectrometry pipeline comparison of tear proteomic analysis to find biomarkers of health and disease
Time of Update: 2022-08-10
They developed an in-strip protein digestion method using a combination of high-energy collisional dissociation and an Orbitrap Fusion Tribrid mass spectrometer to identify 3370 proteins from human tear samples from 11 healthy subjects!ThesisThe tear film is a multi-layered fluid that coats the corneal and conjunctival epithelium of the eye, providing lubrication, nutrition, and protection from the external environment .
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PNAS: How the brain processes smell
Time of Update: 2022-08-10
"Our study shows that different aspects of perception, especially the pleasantness, unpleasantness and quality of smells, arise through different spatial and temporal cortical processing," Kato said .
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Nanoparticles carry inhibitors that can trigger immune system to defeat brain cancer
Time of Update: 2022-08-10
article titleSystemic delivery of an adjuvant CXCR4-CXCL-12 signaling inhibitor encapsulated in synthetic protein nanoparticles for glioma immunotherapy Image: Glioma cellsSource: University of Michigan Roger Cancer CenterScientists at the University of Michigan's Roger Cancer Center are optimistic about the discovery of a small molecule that blocks a key pathway in brain tumors .
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Angew Chemie Int Ed Liu Tao's team made progress in histone epigenetics research
Time of Update: 2022-08-10
On May 30 , 2022 , Liu Tao's team from the State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmacy, Peking University, together with Luo Xiaozhou's team from the Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, and Liu Xiaoyun's team from Peking University's School of Basic Medicine, have published an international journal .
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Biomarkers for Parkinson's disease diagnosis
Time of Update: 2022-08-10
Rapid, low-cost serological testing possibleScience and Technology Daily News (Reporter Liu Xia) Scientists from Kobe University and Hiroshima University in Japan have successfully developed a biomarker, the drug metabolizing enzyme cytochrome P450, which can be quickly and inexpensively diagnosed with only 30 ml of serum samples.
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PNAS: Plasmids can spread between different bacterial 'communities'
Time of Update: 2022-08-10
"Fitness effects of plasmids shape the structure of bacteria–plasmid interaction networks DNA molecules called plasmids, some of which protect bacteria from antibiotics, can spread rapidly through bacterial "colonies" treated with antibiotics, a new study shows .
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Why can't I eat ginger at night?
Time of Update: 2022-08-10
" Why can't you eat ginger at night?
" Why can't you eat ginger at night?
" Why can't you eat ginger at night?
" Why can't you eat ginger at night?
" Why can't you eat ginger at night?
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Nature Medicine: Complications increase plasma biomarker levels associated with Alzheimer's disease
Time of Update: 2022-08-10
" article titlePerformance of plasma phosphorylated tau 181 and 217 in the community A simple blood test to diagnose Alzheimer's disease is an exciting possibility, perhaps even years before symptoms appear, but a new study suggests that before these blood tests are routinely used in clinical diagnostic settings , more research is needed .
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Tumor-infiltrating lymphocyte therapy to file for listing, Iovance share price halved
Time of Update: 2022-08-10
On May 26, Iovance Biotherapeutics reported positive results from the study, codenamed C-144-01, evaluating the company's lead candidate, lifileucel, a tumor-infiltrating lymphocyte (TIL) therapy, in advanced (unresectable or metastatic) disease.
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Tailor your diet to your genotype
Time of Update: 2022-08-10
How much can you know about optimal nutrition if you have DNA information?""Can race, hair color, eye color, ancestry help you choose the best diet?
How much can you know about optimal nutrition if you have DNA information?""Can race, hair color, eye color, ancestry help you choose the best diet?
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Target p53!
Time of Update: 2022-08-10
PC14586 is a potential "first-in-class" small molecule p53 reactivator designed to bind to the p53 Y220C mutant to restore normal p53 protein structure and tumor suppressor function .
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New progress has been made in the molecular mechanism of Kate mango fruit ripening in Kunming Plant
Time of Update: 2022-08-10
Article link Figure 1 MiHY5 directly activates the expression of maturation-related genes Figure 2 The model of ABA regulation of " Keit " fruit ripening Fruits not only play a vital role in plant reproduction and spread, but also provide abundant nutrients for human health .
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Developing a CRISPR to Gene Edit Cockroaches
Time of Update: 2022-08-10
5 million insect species, opening up a future where we can take full advantage of the amazing biological capabilities of insects," Daimon said "By improving the DIPA-CRISPR method, making it more efficient and versatile, we may be able to enable genome editing in nearly all of the more than 1.
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Nature Cell Biology: new database "SpUR" for cancer research
Time of Update: 2022-08-10
. Scientists at KAUST have developed an interactive portal that provides cancer researchers with a platform to study how RNA splicing in noncoding parts of genes promotes the growth of different types of tumors .
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Progress in assessment of current status and future challenges of wild ass conservation in Mongolia, China, Xinjiang habitat
Time of Update: 2022-08-10
Article link: https:// Changes in the distribution area of wild donkeys in China and Mongolia Population Dynamics of Mongolian Wild Ass in Kashan Reserve The Mongolian wild ass is the flagship species in the desert, semi-desert and desert steppe regions of inland Asia .
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Compared with conventional reagents, this reagent can reveal the virus more clearly and in detail
Time of Update: 2022-08-10
article titlePreyssler-type phosphotungstate is a new family of negative-staining reagents for the TEM observation of viruses preyssler-type phosphotungstate, [P5W30O110M(H2O)]n-, the green octahedra and blue tetrahedra represent W-O6 octahedra and P-O4 tetrahedra, respectively, and the gray and black spheres represent the encapsulated cations, respectively M and water oxygen .
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Recent research progress of green electrocatalytic upgrade and recycling of PET waste plastics by Zhao Yixin's team at Shanghai Jiaotong University
Time of Update: 2022-08-10
In the first research work, the researchers successfully converted ethylene glycol in PET hydrolyzate to formic acid products with high selectivity based on low-cost CuO nanowire catalytic anode, using electrocatalytic technology, and co-produced hydrogen at the cathode.
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FDA approves blockbuster PD-1 therapy combination for first-line treatment of esophageal cancer BMS
Time of Update: 2022-08-10
Bristol-Myers Squibb (BMS) announced that the US FDA has approved two treatment regimens based on the blockbuster PD-1 inhibitor Opdivo (nivolumab, nivolumab) (Opdivo in combination with fluoropyrimidine and platinum-containing chemotherapy; Opdivo and Anti-CTLA-4 antibody Yervoy) as first-line therapy for the treatment of advanced unresectable, or metastatic esophageal squamous cell carcinoma .
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New discovery: "Lipid droplet nirvana" initiates a new model of pluripotent stem cell differentiation
Time of Update: 2022-08-10
Paper linkA schematic diagram of lipid droplet-mitochondrial interactions regulating epigenetics and cell fate On May 25, Cell Death & Differentiation published online the latest research results of Liu Xingguo's team from Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences "Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation" (Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation".
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BMJ 30-year follow-up study: the more chronic diseases appear, the higher the risk of dementia
Time of Update: 2022-05-24
Screenshot source: The BMJA large study published in The BMJ recently found that having two or more chronic diseases in midlife may be associated with an increased risk of dementia later in life .
