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Genetic mechanisms of Wilms tumor
Time of Update: 2022-08-11
At-risk patients and tailored treatments for these patients offer hope Published in Cell Reports Medicine, the study identified mutations in key genes, including two previously undetected in Wilms tumor, that could provide the basis for better identification of those with relapses.
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Important progress has been made in the isolation and culture of eel reproductive stem cells in the Aquatic Institute
Time of Update: 2022-08-11
Figure 1 Eel germinal stem cells highly express germline-related genes and proteins The researchers transplanted the isolated and cultured fGSCs into the zebrafish gonads from which the primordial germ cells had been removed, and found Vasa -positive germ cells derived from the eel after 3 months , suggesting that the transplanted fGSCs had successfully colonized and differentiated in the zebrafish gonads, further indicating that the eel - Formation of chimeric gonads in zebrafish .
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Nature: The secret of thymus formation
Time of Update: 2022-08-11
Molecular family tree analysis to identify progenitor cellsIn collaboration with the laboratory of Dominic Grün (Dominic is an expert in single-cell RNA analysis), the researchers have now succeeded in characterizing the unexpected diversity of thymic epithelial cells at the transcriptional level .
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Simple and intuitive new ideas!
Time of Update: 2022-08-11
The natural products (special metabolites) of microorganisms have always been one of the important sources for the development of new drugs, but the relatively few new discoveries and the relatively
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Non-microbiome-independent effects of antibiotics in a mouse model of nosocomial infection
Time of Update: 2022-08-11
. Study of methicillin-resistant Staphylococcus aureus isolates associated with nosocomial infections complicated by lack of susceptibilityin vivoThese strains exhibit extremely low virulence in commonly used animal models of preclinical infection .
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Gao Jianqing and Han Min's team from Zhejiang University School of Pharmacy, Zhejiang University reported in Nature Communications to respond...
Time of Update: 2022-08-10
Schematic diagram of the paper: "Peptide nanoblanket" suppresses the development of the pre-metastatic microenvironment by inhibiting the activation of fibroblasts This study designed and constructed the pre-metastatic microenvironment-responsive post-assembly polypeptide FR17 , and demonstrated that the "polypeptide nano-blanket" formed by post-assembly of FR17 in vivo regulates the formation of the pre-metastatic microenvironment by inhibiting the activation of fibroblasts, and achieves effective tumor metastasis.
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The latest research: Is the "magic drug" metformin really effective in the treatment of breast cancer?
Time of Update: 2022-08-10
Effects of metformin versus placebo on invasive disease-free survival and overall survival While the study found metformin to be ineffective in treating the most common type of breast cancer, the trial found a potentially important result for the treatment of a less common but more aggressive type of breast cancer, HER2-positive breast cancer .
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Rapidly reproducing sea urchins offer new paradigm for genetic research
Time of Update: 2022-08-10
information The research team collected the draft genomes of the sea urchin and constructed two genome databases, TrBase and the Western Pacific Sea Urchin Genome Database (WestPac-SUGDB), which contains the genomes of the sea urchin and another model sea urchin, Hemicentrotus pulcherrimus.
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The major task supervision team of the Chinese Academy of Sciences went to the Institute of Subtropical Ecology to supervise the pilot special sub-project
Time of Update: 2022-08-10
On May 28, the Major Task Supervision Team of the Chinese Academy of Sciences conducted a sub-project of the "Precision Design and Creation of Seeds" under the Strategic Pilot Science and Technology
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The mechanism by which inflammation causes disruption of circadian rhythms
Time of Update: 2022-08-10
Because the circadian clock plays a key role in maintaining the homeostasis of cartilage tissue, as evidenced by changes in gene expression (20) cartilage degeneration (18) Due to disturbances in circadian rhythms, and the recent discovery that inflammation can drive disruption of circadian rhythms in chondrocytes, the goal of this study was to develop tissue engineered cartilage using genetically engineered stem cells to maintain the circadian rhythm of the inflammatory response .
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Circular RNA circCCNB1 inhibits migration and invasion of nasopharyngeal carcinoma
Time of Update: 2022-08-10
Fuyan Wang (Key Laboratory of Tumorgenesis and Tumor Invasion of the Ministry of Education, Institute of Cancer Research, Central South University) found that the oncogene CCBN1 The circular RNA circCCNB1 was down-regulated in nasopharyngeal carcinoma and inhibited the migration and invasion of nasopharyngeal carcinoma cells .
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New study questions previous link between diabetes medication and fractures
Time of Update: 2022-08-10
“Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease,” will appear online at http://cjasn.
“Fracture Risk of Sodium-Glucose Cotransporter-2 Inhibitors in Chronic Kidney Disease,” will appear online at http://cjasn.
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How does a low-glucose, high-lactate environment in tumors affect T cell function?
Time of Update: 2022-08-10
In conclusion, the present study found that hyperglycolytic tumors can release excess lactate, thereby promoting lactate uptake by Treg cells through MCT1, enhancing PD-1 expression, and remodeling Treg cell function and phenotype, which may lead to αPD-1.
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Reindeer Bio's CAR-T Products Accepted Clinical Application for New Autoimmune Disease Indications
Time of Update: 2022-08-10
According to the press release of Reindeer Biology, Iquilonza is a fully human BCMA chimeric antigen receptor (CAR) autologous T cell injection (development code CT103A), and the clinical trial indication declared this time is antibody-mediated optic nerve Myelitis spectrum disorders .
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What is active water?
Time of Update: 2022-08-10
Water is the source of life, a large part of the human body is water, so drinking good water is also a requirement of many people now, because I recently received a kind of water called active water by Amway, so I want to understand it well.
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New sensor for precise measurement of dopamine
Time of Update: 2022-08-10
"However, until now, there has not been a method to simultaneously visualize dopamine signals with high spatiotemporal resolution," explains lead Sebastian Kruss .
"However, until now, there has not been a method to simultaneously visualize dopamine signals with high spatiotemporal resolution," explains lead Sebastian Kruss .
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Institute of Hydrobiology Research Reveals Responses of Functional Diversity of my country's Marine Fisheries to Climate Change and Fishing Intensity
Time of Update: 2022-08-10
Combined with another work by the team ( With the overexploitation of global capture fisheries and increasing climate change in recent decades, these findings will not only enhance the understanding of the broad drivers of changes in the functional diversity of marine fish communities, but also provide insights into the management and management of marine fisheries under multiple pressures.
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Links between 127 genes and immune diseases, gaining insight into the timing of gene activity during cell activation
Time of Update: 2022-08-10
In a first-of-its-kind experiment, researchers have discovered links between 127 genes and immune diseases, providing new insights into the sequence and timing of gene activity during T cell activation, which regulates the body's immune response key process .
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Nature Medicine: Complications increase plasma biomarker levels associated with Alzheimer's disease
Time of Update: 2022-08-10
" article titlePerformance of plasma phosphorylated tau 181 and 217 in the community A simple blood test to diagnose Alzheimer's disease is an exciting possibility, perhaps even years before symptoms appear, but a new study suggests that before these blood tests are routinely used in clinical diagnostic settings , more research is needed .
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Tumor-infiltrating lymphocyte therapy to file for listing, Iovance share price halved
Time of Update: 2022-08-10
On May 26, Iovance Biotherapeutics reported positive results from the study, codenamed C-144-01, evaluating the company's lead candidate, lifileucel, a tumor-infiltrating lymphocyte (TIL) therapy, in advanced (unresectable or metastatic) disease.
