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BMJ 30-year follow-up study: the more chronic diseases appear, the higher the risk of dementia
Time of Update: 2022-05-24
Screenshot source: The BMJA large study published in The BMJ recently found that having two or more chronic diseases in midlife may be associated with an increased risk of dementia later in life .
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Novartis Votrient safe and effective for patients with metastatic renal cell carcinoma!
Time of Update: 2022-05-24
To further evaluate the efficacy and safety of Votrient in real-world clinical practice, we conducted a non-interventional multicenter study (APOLON) in patients receiving first-line Votrient therapy, evaluating progression-free survival (PFS), overall Survival (OS), investigator-assessed objective response rate (ORR), and tolerability .
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AstraZeneca/Daisankyo's heavy ADC welcomes a breakthrough again!
Time of Update: 2022-05-24
On February 21, AstraZeneca and Daiichi Sankyo announced that Enhertu, an antibody-drug conjugate (ADC) jointly developed by the two parties, achieved positive results in the pivotal Phase 3 trial DESTINY-Breast04 .
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New progress in targeted protein degradation!
Time of Update: 2022-05-24
▲The mechanism of action of AUTOphagy-TArgeting Chimera (AUTOTAC) (Image source: Reference [1])Based on this concept, the researchers developed a variety of small-molecule compounds capable of activating p62 and tested their ability to degrade soluble proteins in vitro .
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Exposure to these compounds during pregnancy may affect offspring brain development
Time of Update: 2022-05-24
▲The picture shows the comprehensive framework in this study (picture source: Reference [1])In early pregnancy, the right concentration of thyroid hormone is essential for the growth and development of the brain, therefore, the EDC mixture is likely to cause the delay of neonatal language development through its effect on thyroid hormone .
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TLR4 is a regulator of trained immunity in Duchenne muscular dystrophy
Time of Update: 2022-05-24
In a previous study, the researchers constructed dystrophic mice (mdx mice, a DMD model) lacking the chemokine receptor CCR2 and demonstrated that bone marrow (monocyte)-derived macrophages (BMDMs) in the early stages of disease importance in pathogenesis .
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Is the era of "universal" organ transplants coming?
Time of Update: 2022-05-24
Recently, a new study in Science Translational Medicine brings us one step closer to a universal transplant organ, according to the results of the experiment, the researchers achieved the conversion of donor organ blood type in an extracorporeal lung perfusion device .
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Research progress on anti-HBV effects of natural compounds
Time of Update: 2022-05-24
According to the anti-HBV mechanism of natural compounds found in current research, most active compounds inhibit virus replication in cells by acting on host-related factors, or by regulating the activities of viral S, C and X gene promoters.
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Universal "modular" CAR-T: Innovent continues to develop cell therapy
Time of Update: 2022-05-24
In this collaboration, Innovent can develop 2:1 bispecific T-cell antibodies and general-purpose CAR-T therapy for hematological and solid tumor treatment using Roche's patented technology, and is responsible for product development, manufacturing and commercialization , the specific transaction amount was not disclosed .
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Grid cell networks are impaired in a mouse model of early Alzheimer's disease
Time of Update: 2022-05-23
In a J20 transgenic mouse model of familial AD, coding impairment of the MEC grid cell network that overexpresses aβ in the hippocampus and entorhinal cortex .
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Science: Dopamine secretion in the basolateral amygdala promotes rapid eye movement sleep in the brain
Time of Update: 2022-05-23
The results of the study were published in the journal Science on March 4, 2022, with the title "Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice" .
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Voyager and Novartis reach over $1.7 billion partnership to develop next-generation AAV gene therapy
Time of Update: 2022-05-23
References:[1] Voyager Therapeutics Announces License Option Agreement with Novartis for Target-Specific Access to Next-Generation TRACER™ AAV Capsids for Gene Therapy Programs.
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Wanfu Bio has changed the registration information of the novel coronavirus antigen detection kit
Time of Update: 2022-05-23
Product Change DescriptionProduct Change DescriptionBefore change:Before change:【expected usage】【expected usage】This product is used for the detection of novel coronavirus N antigen in oropharyngeal swabs and nasopharyngeal swab samples of people suspected of novel coronavirus pneumonia .
The product use environment should follow the relevant national regulations such as the "New Coronavirus Antigen Detection Application Program (Trial)" .
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Blueprint Announces Strategic Collaboration with Proteovant to Develop Targeted Protein Degradation Therapies
Time of Update: 2022-05-23
On February 28, 2022, Blueprint Medicines announced a strategic collaboration with Proteovant Therapeutics, a Roivant Sciences company, to discover and develop novel targeted protein degradation therapies aimed at addressing unmet medical needs in cancer and hematological diseases .
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Bristol-Myers Squibb's blockbuster immunotherapy combination receives FDA priority review
Time of Update: 2022-05-23
References:[1] US Food and Drug Administration Accepts for Priority Review Bristol Myers Squibb's Application for Opdivo (nivolumab) Plus Chemotherapy as Neoadjuvant Treatment for Resectable Non-Small Cell Lung Cancer.
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Demethylase ALKBH5 inhibits gastric cancer invasion through PKMYT1 m6A modification
Time of Update: 2022-05-23
Recently, researchers from the Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, published an article entitled "Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification" in the journal Molecular Cancer .
Demethylase ALKBH5 suppresses invasion of gastric cancer via PKMYT1 m6A modification.
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Sci Adv: Scientists hope to develop novel therapy for small cell lung cancer
Time of Update: 2022-05-23
Recently, in a research report titled "KIX domain determines a selective tumor-promoting role for EP300 and its vulnerability in small cell lung cancer" published in the international journal Science Advances, scientists from the University of Virginia and other institutions studied or It is expected to inhibit the occurrence and progression of small cell lung cancer in laboratory mice, an unexpected discovery that may help open the door to the development of new treatments .
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Aging Cell: Scientists Reveal Perredoxin 3 Can Clear Mitochondrial Hydrogen Peroxide To Treat Muscle Atrophy
Time of Update: 2022-05-23
13569Recently, researchers from the Oklahoma Medical Research Foundation published a paper entitled "Scavenging mitochondrial hydrogen peroxide by peroxiredoxin 3 overexpression attenuates contractile dysfunction and muscle atrophy in a murine model of accelerated sarcopenia" in the journal "Aging Cell".
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New insight!
Time of Update: 2022-05-23
Mechanistically, microglial CatE is involved in the secretion of soluble TNF-related apoptosis-inducing ligands in microglia-mediated NF-κB-dependent neuroinflammation and β-site APP cleaving enzyme 1 production of neuronal Aβ play an important role .
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Antibiotic use after birth has important effects on infant gut microbiota and resistance
Time of Update: 2022-05-23
Recently, a research paper titled "Effects of early-life antibiotics on the developing infant gut microbiome and resistome: a randomized trial" published on Nat Commun focused on neonates who received antibiotics within one week of birth.
