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New progress in targeted protein degradation!

 Last Update: 2022-05-24
 Source: Internet
 Author: User

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Targeted protein degradation is a hot area of new drug development.

Autophagy is a way for cells to break down cytoplasmic components such as unwanted or harmful proteins and organelles

Previous studies have found that a receptor called p62 plays a key role in mediating targeted autophagy

▲The mechanism of action of AUTOphagy-TArgeting Chimera (AUTOTAC) (Image source: Reference [1])

Based on this concept, the researchers developed a variety of small-molecule compounds capable of activating p62 and tested their ability to degrade soluble proteins in vitro

In addition, the researchers examined the effect of the AUTOTAC technology on degrading aggregates composed of misfolded proteins

In this study, the scientists designed an AUTOTAC molecule that binds to a tau protein mutant, tauP301L, that readily forms neurofibrillary tangles

Previously, researchers have developed targeted protein degraders (called AUTACs) that stimulate autophagy by inducing specific ubiquitin modifications on the protein surface

References:

[1] Ji et al.

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