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Grid cell networks are impaired in a mouse model of early Alzheimer's disease

 Last Update: 2022-05-23
 Source: Internet
 Author: User

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Early-onset familial Alzheimer's disease (AD) is characterized by an active accumulation of amyloid (Aβ), but the operations affecting neural circuits during the initial stages of Aβ pathogenesis remain unclear

In this study, we recorded spatially regulated neurons in the hippocampus and medial entorhinal cortex (MEC) of a J20 family AD transgenic mouse model expressing mutant forms of human amyloid precursor protein (APP)

We found that early Aβ pathology reduced spatial encoding of grid cells in an age-dependent manner, preceded by widespread expression of Aβ plaques

Fig.

These results suggest that extensive Aβ-mediated damage to the entorhinal-hippocampal circuit leads to early damage to the entorhinal grid cell network

Reference: Ying, J.

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