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March 8, 2022 / Bio Valley BIOON / -- In a new study, researchers from the University of Tsukuba, Japan, and the School of Life Sciences, Peking University, China, discovered the production of dopamine in the basolateral amygdala of the amygdala.
In the paper, they describe their use of optogenetic manipulation in mice to better understand what happens in the brain during sleep cycles
Previous research has shown that people switch between two sleep types when dozing off: non-rapid eye movement (non-REM) sleep and rapid eye movement (REM) sleep
Norepinephrine and serotonin levels in the basolateral amygdala begin to decline before the switch from non-REM sleep to REM sleep
Optogenetic manipulation works by altering the genes of mice so that some of their cells respond to the presence of light (recorded using fiber optic photometry)
The authors' work involved the first observation that cells in the basolateral nucleus of the amygdala were activated during different parts of the sleep cycle
The authors also found that in the brains of narcolepsy mice, stimulating dopamine production in the same region could trigger cataplexy
References:
Emi Hasegawa et al.
Elda Arrigoni et al.
