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Rapid, low-cost serological testing possible
Science and Technology Daily News (Reporter Liu Xia) Scientists from Kobe University and Hiroshima University in Japan have successfully developed a biomarker, the drug metabolizing enzyme cytochrome P450, which can be quickly and inexpensively diagnosed with only 30 ml of serum sampl.
Parkinson's disease is the second most common neurodegenerative disease in the world and has a significant impact on patients' quality of life, potentially affecting 1% to 2% of the population over the age of 6 Scientists have yet to find a simple diagnosis and cure for the disease, so early detection is critical to preventing it from getting worse and developing related dru.
The drug metabolizing enzyme cytochrome P450 not only metabolizes drugs, but also acts as a catalyst for the oxidation of various substanc.
In this assay, 12 different human P450s were mixed with serum samples and fluorogenic substrates to elicit respons.
The researchers conducted a "P450 inhibition test" in Parkinson's disease model rats and human Parkinson's disease patients, and the results showed that, for model rats and human subjects, the accuracy of separating healthy individuals from Parkinson's disease individuals was 8