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Ann Neurol: The relationship between the destruction of the blood-brain barrier and Alzheimer's disease and vascular disease
Time of Update: 2021-06-01
BBB function evaluationCompared with subjects with normal cognition, the permeability of BBB to small molecules (such as water) in MCI patients increased, but the permeability to large molecules (such as albumin) did not increase.
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Nat Med: tau protein in plasma helps predict the risk of Alzheimer's disease
Time of Update: 2021-06-01
The subjects' plasma P-tau, plasma Aβ42/Aβ40, plasma neurofilament light chain, APOE genotype, simple cognitive test and AD-specific magnetic resonance imaging measurement, and recorded whether they have progressed to ADIn BioFINDER, plasma P-tau217 can accurately predict AD within 4 years (area under the curve (AUC) = 0.
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Patients with brainstem hemorrhage, have you ignored this complication?
Time of Update: 2021-06-01
Patients with brainstem hemorrhage often lead to incomplete closure of the upper eyelid due to coma and facial paralysis, and the eye branch of the trigeminal nerve is dull, leading to corneal dryness, inflammatory infiltration, and even corneal ulcers and corneal perforation.
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Nat Neurosci | Large-scale CRISPRi/a Screening Reveals New Mechanism of Neuronal Iron Death
Time of Update: 2021-06-01
On May 24, 2021, Martin Kampmann's team at the University of California, San Francisco published a research article Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis in Nature Neuroscience, which systematically explored how human neurons regulate reactive oxygen species and respond The mechanism of oxidative stress, and unexpectedly discovered a neuron-specific iron death pathway.
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These 5 major cerebral infarction syndromes are mastered in one article
Time of Update: 2021-06-01
▎Locating the cerebellar ataxia transmission pathway The efferent fibers from the cerebellum pass through the upper foot of the cerebellum, cross at the Wernekink commissure, and project to the thalamus after the contralateral red nucleus (dentate nucleus-red nucleus-thalamic tract ).
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Science Advances | Wu Qi's team reports a novel dopamine neural circuit that can dynamically regulate satiety and body weight and a new drug mechanism for targeted treatment of obesity
Time of Update: 2021-06-01
Editor’s note iNature is China’s largest academic official account. It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units
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Can intermittent fasting improve long-term memory?
Time of Update: 2021-06-01
38) on May 25, 2021, an international research team led by King's College London, UK, confirmed through mouse studies that the alternate-day fasting strategy is a gene that promotes longevity An effective means of expression can improve long-term memory consolidation in mice.
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How to establish a high-quality biological sample library for cerebrovascular diseases?
Time of Update: 2021-06-01
Biobank, also known as biobank, refers to the standardized collection, processing, storage, and application of samples of healthy and diseased organisms, as well as clinical, treatment, and follow-up related to these biological samples based on the principles of medical ethics and informed consent of patients The quality control, information management and application system of other materials.
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Neurology: The surrounding socio-economic environment actually affects the outcome of stroke survivors!
Time of Update: 2021-06-01
After adjusting for factors that may affect the score, such as age, the number of other diseases, and how people functioned before the stroke, living in a community with a higher socioeconomic level is moderate compared to living in a community with a lower socioeconomic level.
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JAMA Neurol: Anti-epileptic drug treatment can be stopped after discharge of children with acute symptomatic neonatal epilepsy
Time of Update: 2021-06-01
After the symptoms of children with acute symptomatic neonatal epilepsy were controlled, compared with the out-of-hospital continuation of anti-epileptic drug treatment, there was no significant difference in the 24-month functional neurodevelopment or risk of epilepsy recurrence in the anti-epileptic drug treatment group.
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What is the risk of stroke for these patients with atrial fibrillation who have not started anticoagulation therapy?
Time of Update: 2021-06-01
Given that the current clinical trial data is limited and the recommendations of each guideline are not the same, the team of Professor Husam from Canada conducted an assessment of AF patients aged 66-74 and without other risk factors for CHA2DS2-VASc who are not receiving anticoagulation therapy The study of the risk of stroke in the case of, and explored the relationship between the incidence of stroke and the age of the patient.
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PLOS ONE: Women are more likely to fall than men
Time of Update: 2021-06-01
Excluding people ≤10 years old, women have a higher rate and proportion of falls on stairs of all other age groups.
Excluding people ≤10 years old, women have a higher rate and proportion of falls on stairs of all other age groups.
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Epilepsia: Anti-epileptic drugs increase the risk of major cardiovascular events
Time of Update: 2021-06-01
Compared with the control group, the risk of major cardiovascular events in cases increased (adjusted hazard ratio = 1.
Compared with the control group, epilepsy patients taking antiepileptic drugs have an increased risk of major cardiovascular events .
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JNNP: Subjective Cognitive Complaint at 70: The Relationship Between Amyloid and Mental Health
Time of Update: 2021-06-01
The results of the study show that if the effects of anxiety symptoms are carefully considered, the presence of subjective cognitive symptoms may help identify patients with Alzheimer’s.
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[Nature News] It turns out that if you don’t sleep well, you will really become stupid!
Time of Update: 2021-06-01
In the past, on December 4, 2019, the journal "Physiology" published a titled "Brain Rhythms During Sleep and Memory Consolidation: Neurobiological Insights" Research.
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JNNP: ChAdOx1-nCoV-19 vaccine induced immune thrombotic thrombocytopenia characterized by ischemic stroke
Time of Update: 2021-06-01
Young patients with ischemic stroke after receiving ChAdOx1-nCoV-19 vaccine should immediately evaluate VITT through laboratory tests (including platelet count, D-dimer, fibrinogen, and anti-PF4 antibodies), and evaluate whether there are concurrent veins thrombosis; patients should be by a multidisciplinary team (hematology, neurology, stroke, neurosurgery and neuroradiology) management , for quick access to treatment, including intravenous immunoglobulin, methylprednisolone, and non-plasma exchange Heparin anticoagulants, such as Fondaparinux, Argatroban, or direct oral anticoagulants.
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JAMA: A quarter of adults in our country have an extra "mind eye", which will not only cause headaches, but also strokes!
Time of Update: 2021-06-01
do?w=%E5%BF%83%E8%A1%80%E7%AE%A1">Cardiovascular JAMAThe researchers used a high-resolution optical coherence tomography (OCT) technique to assess the microstructure of blood vessels, aiming to initially analyze the difference in in situ thrombus in the PFO between stroke and non-stroke patients .
com/journals/jama/article-abstract/2780339?resultClick=1" target="_blank" rel="noopener">Preliminary Investigation of In situ Thrombus Within Patent Foramen Ovale in Patients With and Without Strok e.
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Nat Neurosci: GWAS and meta-analysis reveal the genetic structure of depression and new treatment directions
Time of Update: 2021-06-01
The study reports a large meta-analysis that integrates the Psychiatric Genomics Consortium (PGC), the British Biobank (UKB), the FinnGen database and the 23andMe database , and has made substantial progress in the study of the underlying genetic structure of depression.
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2021 Emergency Diagnosis and Treatment Guidelines for Vertigo Released, 3 Minutes Reading | Guidelines Consensus
Time of Update: 2021-06-01
Central vertigo (1) Acute cerebrovascular disease: For hyperacute cerebral infarction, those who meet the indications will be given emergency intravenous thrombolysis (alteplase, urokinase), intravascular interventional therapy and other rescue measures, and the loss of vascular recanalization Those who have the opportunity can be treated according to TOAST classification, such as anti-platen or anti-coagulation, lipid-lowering, control of risk factors, and plaque stabilization (statin drugs).
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Express | Effectively improve cognitive impairment, innovative therapy is recognized by FDA as a breakthrough therapy
Time of Update: 2021-06-01
Boehringer Ingelheim plans to initiate a phase 3 clinical trial of BI 425809 to evaluate the safety and effectiveness of the drug in improving the cognition of adults with schizophrenia.
"Reference: [1] Boehringer Ingelheim's Investigational Treatment for Cognitive Impairment Associated with Schizophrenia Receives FDA Breakthrough Therapy Designation.
