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JNNP: ChAdOx1-nCoV-19 vaccine induced immune thrombotic thrombocytopenia characterized by ischemic stroke

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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In ChAdOx1 nCoV-19 encoding SARS-CoV-2.

Immune Thrombosis Here, this article reports three VITT patients with ischemic stroke.

Patient 1, a 35-year-old Asian female, had onset of right temporal and periorbital headache a few days after receiving ChAdOx1-nCoV-19 vaccine.

Blood vessel

Patient's cerebrovascular impact

Person 2 was a 37-year-old white female who developed diffuse headache, loss of left visual field, confusion, and left arm weakness 12 days after the ChAdOx1 nCoV-19 vaccine.

Patient 3, a 43-year-old Asian male, developed a language barrier 21 days after the ChAdOx1 nCoV-19 vaccine.

Observations have shown that in addition to venous thrombosis, the clinical symptoms of VITT include arterial occlusion.

Management includes intravenous immunoglobulin, methylprednisolone, plasma exchange, and non-heparin anticoagulants such as fondaparinux, argatroban, or direct oral anticoagulants.
Endovascular treatment or decompressive craniectomy can also be used for carefully selected patients Al-MayhaniT ,SaberS ,StubbsMJ Al-MayhaniT Al-Mayhani SaberS Saber StubbsMJ Stubbs , et al bmj.
com/content/early/2021/05/20/jnnp-2021-326984" target="_blank" rel="noopener">Ischaemic stroke as a presenting feature of ChAdOx1 nCoV-19 vaccine-induced immune thrombotic thrombocytopaenia Journal of Neurology, Neurosurgery & Psychiatry Published Online First: 25 May 2021.
Published Online First: doi: 10.
1136/jnnp-2021-326984 doi:

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