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Ann Neurol: The relationship between the destruction of the blood-brain barrier and Alzheimer's disease and vascular disease

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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The destruction of the blood-brain barrier (BBB) is considered an early biomarker of human cognitive impairment.

Blood vessel

Recently, an authoritative journal in the field of neurology published a research article in Annals of Neurology.

The study included 55 elderly participants, including 33 MCI patients and 22 controls.

BBB function evaluation

Compared with subjects with normal cognition, the permeability of BBB to small molecules (such as water) in MCI patients increased, but the permeability to large molecules (such as albumin) did not increase.

cholesterol

These results provide early evidence that BBB destruction is related to both AD and vascular risk, but its effects can be distinguished by spatial scale.

Original source:

BS Zixuan Lin,et al.

wiley.
com/doi/10.
1002/ana.
26134" target="_blank" rel="noopener">Blood-brain barrier breakdown in relationship to Alzheimer and vascular disease

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