-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
Intermittent fasting (IF) strategies have been proven to lose weight and extend lifespan in many species and improve cognitive abilities, including extensive health improvements during the aging process of rodents, primates, and humans.
Recent studies have emphasized that switching to a healthy diet after fasting can be used as a non-drug intervention for patients with hypertension and metabolic syndrome.
Intermittent fasting is usually divided into three forms: one is to eat at a limited time each day, that is, to narrow the eating period to 6 to 8 hours; the other is the so-called "5:2", which means eating normally 5 days a week , The remaining two days eat very little; another is fasting every other day, that is, eating normally on the first, third, fifth, and seventh days, and completely fasting on the second, fourth, sixth, and eighth days (drinking water or meal replacement during the period).
Previously, intermittent fasting has also been shown to enhance learning ability and memory consolidation, and partially reverse the impairment of age-related rodents' motor coordination and memory function.
But researchers still know little about the mechanism behind it.
In a new study published in "Molecular Psychiatry" (IF=12.
38) on May 25, 2021, an international research team led by King's College London, UK, confirmed through mouse studies that the alternate-day fasting strategy is a gene that promotes longevity An effective means of expression can improve long-term memory consolidation in mice.
The longevity gene, namely Klotho.
Its discovery came from an accident.
The story starts in 1997, when a group of scientists accidentally harvested a mouse with a phenotype similar to human aging while studying spontaneous hypertension.
This kind of mouse was named Klotho mouse.
The study found that Klotho-deficient mice showed signs of premature aging at 5 to 8 weeks of age, and their lifespan was shortened by 80%; while the lifespan of Klotho-overexpressing mice was greatly extended, and female mice were prolonged by 19%.
The male rat prolonged by 30.
8%.
In short, the lack of Klotho leads to premature aging, and the increase in Klotho expression leads to prolonged life.
Although Klotho is mainly produced in the kidneys, it is also highly expressed in certain brain regions, including the dentate gyrus (DG) of the hippocampus, especially in its mature neurons.
The function of Klotho in the brain is still a mystery, but previous studies have suggested that Klotho plays an important role in cognition, because the increased serum level of a protein it produces is related to the enhanced cognitive ability of humans and rodents.
In this study, the researchers divided the female mice into three groups: a standard diet group (control), a calorie-restricted diet group, and an intermittent fasting group that was fed every other day.
The latter two groups consumed 10% less calories than the control group.
In three months, compared with the other two groups, the mice in the intermittent fasting group showed better long-term memory consolidation ability.
The researchers studied the brains of these mice and confirmed that Klotho is an important regulator of adult hippocampal neurogenesis, and proposed that it is a new molecular mechanism through which intermittent fasting may improve cognitive ability .
The corresponding author of the study, Dr.
Sandrine Thuret, of the Department of Basic and Clinical Neuroscience at the Institute of Psychology and Neuroscience at King's College London, said: "We now have a deeper understanding of why intermittent fasting promotes adult neurogenesis.
Our research The results show that Klotho is not only necessary, but also plays a central role in adult neurogenesis.
This research shows that intermittent fasting can be an effective means to improve human long-term memory.
"Researchers now hope to repeat this among human participants.
Research in order to further explore the effects of intermittent diet. Link to the paper: Hot Article Selection in 2020 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
Recent studies have emphasized that switching to a healthy diet after fasting can be used as a non-drug intervention for patients with hypertension and metabolic syndrome.
Intermittent fasting is usually divided into three forms: one is to eat at a limited time each day, that is, to narrow the eating period to 6 to 8 hours; the other is the so-called "5:2", which means eating normally 5 days a week , The remaining two days eat very little; another is fasting every other day, that is, eating normally on the first, third, fifth, and seventh days, and completely fasting on the second, fourth, sixth, and eighth days (drinking water or meal replacement during the period).
Previously, intermittent fasting has also been shown to enhance learning ability and memory consolidation, and partially reverse the impairment of age-related rodents' motor coordination and memory function.
But researchers still know little about the mechanism behind it.
In a new study published in "Molecular Psychiatry" (IF=12.
38) on May 25, 2021, an international research team led by King's College London, UK, confirmed through mouse studies that the alternate-day fasting strategy is a gene that promotes longevity An effective means of expression can improve long-term memory consolidation in mice.
The longevity gene, namely Klotho.
Its discovery came from an accident.
The story starts in 1997, when a group of scientists accidentally harvested a mouse with a phenotype similar to human aging while studying spontaneous hypertension.
This kind of mouse was named Klotho mouse.
The study found that Klotho-deficient mice showed signs of premature aging at 5 to 8 weeks of age, and their lifespan was shortened by 80%; while the lifespan of Klotho-overexpressing mice was greatly extended, and female mice were prolonged by 19%.
The male rat prolonged by 30.
8%.
In short, the lack of Klotho leads to premature aging, and the increase in Klotho expression leads to prolonged life.
Although Klotho is mainly produced in the kidneys, it is also highly expressed in certain brain regions, including the dentate gyrus (DG) of the hippocampus, especially in its mature neurons.
The function of Klotho in the brain is still a mystery, but previous studies have suggested that Klotho plays an important role in cognition, because the increased serum level of a protein it produces is related to the enhanced cognitive ability of humans and rodents.
In this study, the researchers divided the female mice into three groups: a standard diet group (control), a calorie-restricted diet group, and an intermittent fasting group that was fed every other day.
The latter two groups consumed 10% less calories than the control group.
In three months, compared with the other two groups, the mice in the intermittent fasting group showed better long-term memory consolidation ability.
The researchers studied the brains of these mice and confirmed that Klotho is an important regulator of adult hippocampal neurogenesis, and proposed that it is a new molecular mechanism through which intermittent fasting may improve cognitive ability .
The corresponding author of the study, Dr.
Sandrine Thuret, of the Department of Basic and Clinical Neuroscience at the Institute of Psychology and Neuroscience at King's College London, said: "We now have a deeper understanding of why intermittent fasting promotes adult neurogenesis.
Our research The results show that Klotho is not only necessary, but also plays a central role in adult neurogenesis.
This research shows that intermittent fasting can be an effective means to improve human long-term memory.
"Researchers now hope to repeat this among human participants.
Research in order to further explore the effects of intermittent diet. Link to the paper: Hot Article Selection in 2020 1.
The cup is ready! A full paper cup of hot coffee, full of plastic particles.
.
.
2.
Scientists from the United States, Britain and Australia “Natural Medicine” further prove that the new coronavirus is a natural evolution product, or has two origins.
.
.
3.
NEJM: Intermittent fasting is right The impact of health, aging and disease 4.
Heal insomnia within one year! The study found that: to improve sleep, you may only need a heavy blanket.
5.
New Harvard study: Only 12 minutes of vigorous exercise can bring huge metabolic benefits to health.
6.
The first human intervention experiment: in nature.
"Feeling and rolling" for 28 days is enough to improve immunity.
7.
Junk food is "real rubbish"! It takes away telomere length and makes people grow old faster! 8.
Cell puzzle: you can really die if you don't sleep! But the lethal changes do not occur in the brain, but in the intestines.
.
.
9.
The super large-scale study of "Nature Communications": The level of iron in the blood is the key to health and aging! 10.
Unbelievable! Scientists reversed the "permanent" brain damage in animals overnight, and restored the old brain to a young state.
.
.
