-
JAMA Neurology: The Effect of Methylphenidate on Apathy in Patients with Alzheimer's Disease--ADMET-2 Randomized Clinical Trial
Time of Update: 2021-12-03
In order to more accurately clarify the clinical efficacy of methylphenidate in the treatment of Alzheimer's disease indifference, some researchers have recently conducted a larger, longer, and more effective test: methylphenidate dementia indifference test 2 (ADMET 2), a phase 3, placebo-controlled, blinded, 6-month multicenter randomized clinical trial involving 200 patients with apathy and Alzheimer's disease .
-
Alz Res Therapy: Genome-wide penetrance relationship analysis may predict the genetic risk of dementia
Time of Update: 2021-12-03
Through genome-wide epigenetic analysis, new genetic interactions that may be involved in AD can be determined; ERS can be used as an indicator of AD genetic risk .
-
Alz Res Therapy: How does the cognitive trajectory of patients with focal amyloid deposits change?
Time of Update: 2021-12-03
Finally, a mixed effect model was used to study the speed of cognitive decline in the Focal-FMM group compared with the No- or Diffuse-FMM group, according to the cognitive level, degree and location of Aß involvement .
-
Neurology: Eating more fish is good for cardiovascular and cerebrovascular health
Time of Update: 2021-12-03
Higher fish intake is associated with lower CVD burden, especially among participants younger than 75 years of age, which suggests a beneficial effect on cerebrovascular health before the emergence of overt brain disease .
-
JAMA Neurology: The effect of levetiracetam on the cognitive function of patients with Alzheimer's disease with and without epileptiform activities
Time of Update: 2021-12-03
Levetiracetam Levetiracetam Recently, researchers have evaluated the ability of levetiracetam to improve the cognitive function of AD patients in an attempt to explore whether patients with Alzheimer's disease and epileptiform activity respond to levetiracetam treatment more than those without this nerve Patients with signs of network hypersynchronization are better .
-
Stroke: Do patients with mild ischemic stroke need to pay attention?
Time of Update: 2021-12-03
Mild patients have longer time from onset of symptoms to evaluation (from onset to CT examination [240 minutes vs 167 minutes] and CTA [246 minutes vs 172 minutes]), and more distal occlusions (M3, anterior cerebral artery and brain) Posterior artery: 22% vs 6%), higher thrombus burden score (median, 9[6-9] vs 6[4-9]), but similar favorable thrombus permeability (residual flow grade I-II, 21% vs 19%), higher collateral flow (9.
-
Expert lecture hall Lu Jubao: Analysis of the therapeutic advantages of new antipsychotics from the perspective of receptor pharmacology
Time of Update: 2021-12-03
In general, cariprazine is a new type of antipsychotic drug that can change clinical decision-making, especially for patients with schizophrenia with negative symptoms .
-
JNER: The feasibility and preliminary effect of combined intervention of virtual reality, robot and electrical stimulation on upper limb stroke rehabilitation
Time of Update: 2021-12-03
Advances in rehabilitation technology, especially robotics, virtual reality (VR) and neuromuscular electrical stimulation (NMES), have been shown to be effective in improving the UE function of stroke patients by providing such repetitive and task-oriented training .
-
Alz Res Therapy: weight loss, or may predict pathological changes in AD
Time of Update: 2021-12-03
In the past few years, studies incorporating AD biomarkers have shown a higher baseline level of amyloid β (Aβ) deposition measured by positron emission tomography (PET) and a higher ratio of tau/Aβ42 in cerebrospinal fluid (CSF) Levels are associated with greater prospective weight loss, and a recent study reported a negative correlation between changes in BMI and the burden of amyloid β-PET .
-
Stroke: Analysis of Smoking Cessation among Stroke Survivors in the United States
Time of Update: 2021-12-03
It can be seen that there are considerable demographic and geographic differences in the smoking cessation rate of stroke survivors, and they are less likely to quit smoking compared with cancer survivors .
-
Alzheimers Dement: Patients with dementia are at increased risk of COVID-19
Time of Update: 2021-12-03
published a research article in Alzheimers Dement, testing the impact of gender, race, and age on the relationship between dementia and COVID-19 in the United States .
-
Muscle atrophy, back pain, and nerve root hypertrophy turned out to be this kind of disease!
Time of Update: 2021-12-03
Peroneal muscular atrophy ( Charcot-Marie-tooth disease , CMT ), also known as hereditary motor and sensory neuropathy ( HMSN ), is a group of peripheral nerve single-gene genetic diseases with high clinical and genetic heterogeneity .
-
Significant progress in new stem cell drugs: Multiple sclerosis is being studied, T-MSC stem cell new drug completed the first patient medication in the United States
Time of Update: 2021-12-03
After complete animal safety and effectiveness verification, and large-scale production quality control research, T-MSC's new drug under development has obtained the world's first FDA clinically approved new human embryo-derived mesenchymal stem cell drug for multiple sclerosis Disease treatment .
-
IEEE trans: Using fNIRS to classify depression in sports rehabilitation
Time of Update: 2021-12-03
The purpose of this study is to confirm the feasibility of fNIRS to assess and classify depression through exercise rehabilitation tasks .
The purpose of this study is to confirm the feasibility of fNIRS to evaluate and classify depression through exercise rehabilitation tasks .
-
Lancet Psychiatry: True or false?
Time of Update: 2021-12-03
Mendelian randomization analysis showed that the concentration of long-chain omega-3 and omega-6 fatty acids was associated with a 17% reduction in the risk of schizophrenia (docosahexaenoic acid: OR=0.
The concentration of long-chain omega-3 and omega-6 fatty acids is associated with a 17% reduction in the risk of schizophrenia (docosahexaenoic acid: OR=0.
-
Sleep: During the COVID-19 lockdown, how did exposure to electronic devices at night affect our sleep?
Time of Update: 2021-12-03
references:Changes of evening exposure to electronic devices during the COVID-19 lockdown affect the time course of sleep disturbances, Sleep , Volume 44, Issue 9, September 2021, zsab080, https://doi.
-
Mol Psychiatry: Higher schizophrenia types are associated with thicker mOFC/vmPFC
Time of Update: 2021-12-03
Recently, the SZ working group of the ENIGMA (enhanced neuroimaging genetics through meta-analysis) consortium provided meta-analysis evidence of strong abnormalities in the subcortical volume, cortical thickness, and surface area of the SZ, and also showed that these abnormalities may be affected by disease severity and antipsychotic The effects of drugs .
-
Neuropathol. Appl. Neurobiol: The thinning of the cerebral cortex in patients with epilepsy is related to the activation of microglia
Time of Update: 2021-12-03
In the mouse model, the transient depletion of activated microglia prevents the thinning of the temporal cortex and the loss of neuronal cells in the early stages of disease development .
-
Professor Qu Yan from the expert lecture hall: Prospects and challenges of immunotherapy for glioma
Time of Update: 2021-12-03
A phase I/II clinical study (NCT00846456) used DC vaccine loaded with GBM stem cell mRNA to treat patients and found that the progression-free survival of patients in the treatment group was 2.
-
IEEE trans: EMG control interface for upper limb robot rehabilitation after spinal cord injury
Time of Update: 2021-12-03
For each situation (ie, participant and control mode), the program is divided into three stages: calibration of active contraction and resting state; training data collection and classifier fitting; online testing of classifier performance .
The average classification accuracy of the single-degree-of-freedom control mode is between 85.
