Mol Psychiatry: Higher schizophrenia types are associated with thicker mOFC/vmPFC

Evidence from neuroimaging research also supports the dimensional view of psychosis
.

Recently, the SZ working group of the ENIGMA (enhanced neuroimaging genetics through meta-analysis) consortium provided meta-analysis evidence of strong abnormalities in the subcortical volume, cortical thickness, and surface area of ​​the SZ, and also showed that these abnormalities may be affected by disease severity and antipsychotic The effects of drugs

Evidence from neuroimaging research also supports the dimensional view of psychosis

Gemma Modinos et al.

The sample included 3004 healthy individuals (12-68 years old, 46.
5% male) without drug treatment, from 29 cohorts of the global ENIGMA split type working group
.

A standardized method was used to generate cortical and subcortical effect size maps with split-type scores

By comparing schizophrenia (SZ), bipolar disorder (BD), and major depression (MDD) patients with schizophrenia-related cortex and subcortical maps and effect size maps, the pattern similarity was evaluated
.

Partial correlation between cortical thickness, surface area and split type (r)
.

Partial correlation between cortical thickness, surface area and split type (r)
.

Thicker right medial orbitofrontal cortex/ventromedial medial prefrontal cortex (mOFC/vmPFC) is associated with a higher schizotypic score (r = 0.
067, P _FDR = 0.
02)
.

The distribution of cortical thickness in schizophrenia patients is positively correlated with cortical abnormalities in SZ patients (r = 0.

_{FDR spin spin spin}

Cortical map of the effect size of the split-type association area
.

Cortical map of the effect size of the split-type association area
.

In SZ (rho = 0.
690, pspin = 0.
006), BD (rho = 0.
672, P _spin = 0.
009) and MDD (rho = 0.
692, P _spin = 0.
004), the subcortical volume pattern associated with the split type is similar to subcortical abnormalities.
Negative correlation
.

_{spin spin}

Pattern similarity between the cortical thickness effects of schizophrenia and major mental disorders
.

Pattern similarity between the cortical thickness effects of schizophrenia and major mental disorders
.

The pattern similarity of the subcortical volume effect between schizophrenia and major mental disorders
.

The pattern similarity of the subcortical volume effect between schizophrenia and major mental disorders
.

Regardless of the confounding effects of antipsychotic drugs or chronic diseases, a comprehensive map of brain morphometry related to schizophrenia in the general population shows that there is a significant difference between the higher schizophrenia and the thicker mOFC/vmPFC Relationship
.

There is a significant relationship between the higher split type and the thicker mOFC/vmPFC
.

There is a significant relationship between the higher split type and the thicker mOFC/vmPFC

CT abnormalities including thicker prefrontal cortex are associated with more severe schizophrenia

Original source

Kirschner, M.

Kirschner, M.
, Hodzic-Santor, B.
, Antoniades, M.
et al.
Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
Mol Psychiatry (2021).
Kirschner, M.
, Hodzic-Santor , B.
, Antoniades, M.
et al.
Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study.
Mol Psychiatry (2021).
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