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Although studies have shown that in patients with schizophrenia, the concentration of omega-3 and omega-6 fatty acids is low, there is little evidence of the beneficial effects of fatty acid supplementation
.
In order to determine whether the concentration of omega-3 and omega-6 fatty acids is causally related to schizophrenia, experts from the Mental Health Center of the Medical College of Bristol in the United Kingdom conducted a related study, and the results were published in the journal Lancet Psychiatry
In patients with schizophrenia, the concentration of omega-3 and omega-6 fatty acids is low, and in patients with schizophrenia , the concentration of omega-3 and omega-6 fatty acids is low.
GWAS
Weighted median, weighted model, and Mendelian randomized Egger regression method were used as sensitivity analysis
.
In order to solve the potential mechanism problem, a single tool was used for further analysis within the FADS gene cluster and the ELOVL2 gene locus
Mendelian randomization analysis showed that the concentration of long-chain omega-3 and omega-6 fatty acids was associated with a 17% reduction in the risk of schizophrenia (docosahexaenoic acid: OR=0.
83[95%CI 0.
75-0.
92])
.
In contrast, short-chain omega-3 and short-chain omega-6 fatty acids are associated with an increased risk of schizophrenia (α-linolenic acid: OR=1.
The concentration of long-chain omega-3 and omega-6 fatty acids is associated with a 17% reduction in the risk of schizophrenia (docosahexaenoic acid: OR=0.
The effect of sensitivity analysis and FADS single SNP analysis is consistent, indicating that the concentration of long-chain omega-3 and long-chain omega-6 fatty acids is associated with a lower risk of schizophrenia, while short-chain omega-3 and short-chain omega-6 Fatty acid concentration is associated with an increased risk of schizophrenia
.
Multivariate Mendelian randomization showed that the protective effect of docosahexaenoic acid on schizophrenia still exists after being conditioned by other lipids (OR 0.
Multivariate Mendelian randomization showed that the protective effect of docosahexaenoic acid on schizophrenia still exists after being conditioned by other lipids (OR 0.
In summary, the concentration of long-chain omega-3 and long-chain omega-6 fatty acids is associated with a lower risk of schizophrenia
Associations between plasma fatty acid concentrations and schizophrenia: a two-sample Mendelian randomisation study.
Associations between plasma fatty acid concentrations and schizophrenia: a two-sample Mendelian randomisation study.
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