Neuropathol. Appl. Neurobiol: The thinning of the cerebral cortex in patients with epilepsy is related to the activation of microglia

In common humansIn epilepsy , a significant reduction in the thickness of the cerebral cortex is detectable on neuroimaging and has important clinical consequences, but the cause is not clear
.

In common humansIn epilepsy , a significant reduction in the thickness of the cerebral cortex is detectable on neuroimaging and has important clinical consequences, but the cause is not clear
.

epilepsy

Sanjay M.
Sisodiya et al.
used system-level analysis to study the underlying mechanism of cortical thinning
.

Cell type deconvolution, differential expression analysis and cell type enrichment analysis were used to identify differences in cell type distribution

Sanjay M.

Analysis process

Analysis process

There are over-activated microglia in the brain tissue of patients with epilepsy after death
.

There are over-activated microglia in the brain tissue of patients with epilepsy after death
.

The study found an increase in microglia and endothelial cells in areas with reduced cortical thickness
.

The differentially expressed genes showed an enrichment of microglia markers, especially the activated microglia state

The study found an increase in microglia and endothelial cells in areas with reduced cortical thickness

The effect of the loss of microglia in the early stage of the disease on the thickness of the entorhinal cortex, the loss of neuronal cells and cognitive deficits in epileptic mice

The effect of the loss of microglia in the early stage of the disease on the thickness of the entorhinal cortex, the loss of neuronal cells and cognitive deficits in epileptic mice

 In the mouse model, the transient depletion of activated microglia prevents the thinning of the temporal cortex and the loss of neuronal cells in the early stages of disease development
.

Although the development of chronic seizures was not affected, epileptic mice with early loss of microglia did not show defects in non-spatial memory tests

 In the mouse model, the transient depletion of activated microglia prevents the thinning of the temporal cortex and the loss of neuronal cells in the early stages of disease development

These pooled data strongly imply the presence of activated microglia in the thinning area of ​​the cortex, representing a new dimension of concern and disease changes that may be different from epilepsy control

 The study pointed out the important role of neuroinflammatory pathways and potential specific molecules, such as IFN-γ

Altmann, A.

Altmann, A.
et al.
A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies.
Neuropathol.
Appl.
Neurobiol.
Altmann, A.
et al.
A systems-level analysis highlights microglial activation as a modifying factor in common epilepsies.
Neuropathol.
Appl.
Neurobiol.
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