-
For rheumatoid arthritis, don’t only care about inflammation, and osteoporosis should not be underestimated!
Time of Update: 2022-08-16
The activity of cells and osteocytes adversely affects bone remodeling Glucocorticoids are a class of drugs that are widely used clinically in patients with rheumatoid arthritis.
Reducing the activity of osteoblasts and osteocytes adversely affects bone remodeling Glucocorticoids are a class of drugs that are used more clinically in patients with rheumatoid arthritis.
-
This "alkali" method of soda water is far from preventing gout!
Time of Update: 2022-08-16
Some time ago , the entry "Can drinking soda water prevent gout?" became popular, arousing curiosity and extensive discussion among the public. Among them, there are many gout patients who "voluntaril
-
A&R: Mechanisms of interleukin-1β-activated microvascular endothelial cells in skin fibrosis in systemic sclerosis
Time of Update: 2022-08-16
OBJECTIVE : To characterize the role of interleukin 1 beta (IL-1 beta ) and microvascular endothelial cells (MVEC) in the generation of alternately activated macrophages in the skin and to investigate their role in systemic sclerosis (SSc , scleroderma ) in the development of skin fibrosis in patients .
-
ARD: Prevention of disease flares by risk adaptation stratification of treatment withdrawal in juvenile idiopathic arthritis: results from the PREVENT-JIA trial
Time of Update: 2022-08-16
Methods : This multicenter trial (PREVENT-JIA) enrolled 119 patients with JIA in clinical remission , 100 of whom entered the intervention phase to continue or discontinue treatment based on S100A12 and hsCRP levels .
-
ARD: EULAR recommendations for cardiovascular risk management in rheumatic and musculoskeletal diseases, including systemic lupus erythematosus and antiphospholipid syndrome
Time of Update: 2022-08-16
Purpose : For gout, vasculitis, systemic sclerosis (SSc) , myositis, mixed connective tissue disease (MCTD) , Sjögren's syndrome (SS) , systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS) Develop recommendations for cardiovascular risk (CVR) management .
-
A&R: Antiphospholipid antibodies increase endometrial stromal cell decidualization, aging, and inflammation via Toll-like receptor 4, reactive oxygen species, and p38 MAPK signaling
Time of Update: 2022-08-16
. Methods : EnSCs under decidual conditions were exposed to aPL or control IgG alone, or to Toll-like receptor 4 (TLR-4) antagonist, p38 MAPK (mitogen-activated protein kinase) inhibitor, reactive oxygen species (ROS) inhibitor agents, low molecular weight heparin (LMWH), or acetylsalicylic acid .
-
A&R: Intensive oral uric acid lowering does not improve bone erosion scores in erosive gout patients
Time of Update: 2022-08-16
42055 Leave a comment here Objective : To determine whether intensive serum uric acid-lowering therapy improves bone erosion scores in patients with erosive gout .
42055 Leave a comment here Objective : To determine whether intensive serum uric acid-lowering therapy improves bone erosion scores in patients with erosive gout .
-
Rheumatology: Associations between psoriasis and lifestyle factors and comorbidities - a cross-sectional analysis and Mendelian randomization
Time of Update: 2022-08-16
Psoriatic Arthritis (PsA) Psoriatic Arthritis (PsA) Psoriasis Life>ComorbiditiesMETHODS: Cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, and 36000 controls) were analysed using logistic models adjusted for age, gender and life>BMI and smoking ) and 15 comorbidities including diabetes and coronary artery disease (CAD ) .
-
A&R: Common features of anti-SSA/Ro60 antibody expression in autoimmune diseases
Time of Update: 2022-08-16
Objective : Anti- Ro autoantibodies are one of the most frequently detected autoantibodies to extractable nuclear antigens and are mainly associated with primary Sjögren's syndrome (pSS) , systemic lu
-
A&R: Prevalence of Site-Specific Osteoarthritis 1990-2019: Findings from the Global Burden of Disease Study 2019
Time of Update: 2022-08-16
Objectives To estimate systemic and anatomical site-specific age-standardized prevalence rates (ASR) of osteoarthritis (OA) and to analyze long-term trends in OA at global, regional, and national levels .
-
HCQ may have slight benefit for proteinuria in patients with IgA nephropathy
Time of Update: 2022-08-16
Flowchart of path selection:Flowchart of path selection:Methods: PubMed and Embase were systematically searched for studies through June 2021 comparing HCQ and other treatments to reduce proteinuria in patients with IgA nephropathy .
-
dry mouth?
Time of Update: 2022-08-16
. Patients often complain of dysphagia , food sticking to the surface of the mouth, difficulty eating and swallowing dry foods such as biscuits without drinking water; dentures, altered taste, and difficulty speaking continuously for extended periods of time .
-
An article to sort out the mechanism of action of hydroxychloroquine (HCQ) and chloroquine (CQ)
Time of Update: 2022-08-16
Affecting multiple cellular pathways through different mechanisms, CQ and HCQ inhibit multiple endolysosomal functions, including autophagy, as well as endosomal Toll-like receptor activation and calcium signaling , as the therapeutic use of HCQ is expanding to treat both malaria and RAD.
-
A&R: B cell counts predict humoral and cellular responses to SARS-CoV-2 vaccine in patients receiving rituximab
Time of Update: 2022-08-16
. In RTX-treated patients, at least 10 B cells per microliter in the peripheral circulation are a candidate biomarker with a high likelihood of appropriate cellular and humoral responses following SARS-CoV-2 vaccination .
-
Hair loss in SLE patients is a recurrence?
Time of Update: 2022-08-16
Excessive intake of nutrients (eg: iron, copper, zinc) (vitamins B2, C, E, H) (eg vitamin A and selenium)frequent shampooingWashing hair too frequently, especially using overly powerful shampoo products , and vigorously scratching the scalp during shampooing can damage the cortex, weaken the skin barrier, and make the oil secretion more vigorous, resulting in itchy scalp It even stimulates hair follicles, causing seborrheic dermatitis or microbial infection to cause hair loss [4] .
-
A&R: Dynamic changes in CpG site methylation associated with SLE subtypes in a longitudinal cohort
Time of Update: 2022-08-16
Paired t -tests were used to identify changes in 256 CpG loci previously associated with SLE subtypes as well as genome- wide .
Paired t -tests were used to identify changes in 256 CpG loci previously associated with SLE subtypes as well as genome- wide .
-
ARD: biological insights into systemic lupus erythematosus from immune cell-specific transcriptome association studies
Time of Update: 2022-08-16
OBJECTIVE : Genome-wide association studies (GWAS) have identified more than 100 systemic lupus erythematosus (SLE) risk loci, but disease genes at most loci remain unclear, hindering translation of these gene discoveries .
-
Rheumatology (Oxford): How effective are adipose tissue-derived stromal vessels in patients with systemic sclerosis?
Time of Update: 2022-08-16
A study published in Rheumatology (Oxford) evaluated the superiority of finger injection of adipose tissue-derived stromal vascular fraction (AD-SVF) compared with placebo in reducing hand disability in patients with SSc .
-
A&R: Interleukin-4-induced epithelial cell senescence as a novel therapeutic target for IgG4-related sialadenitis
Time of Update: 2022-08-16
. RESULTS : Salivary acinar and ductal epithelial cells undergo senescence in IgG4-RS patients with increased senescence-associated β - galactosidase activity, lipofuscin accumulation, enhanced expression of senescence markers ( p53 and p16 INK4A ), and senescence-associated The secreted phenotype factor was up-regulated .
-
A&R: Epigenetic regulation of profibrotic macrophages in systemic sclerosis-associated interstitial lung disease
Time of Update: 2022-08-16
Single Cell RNA Sequencing Single Cell ATAC Sequencing Signac/Seurat Binding Site Transcription FactorsRESULTS: By scRNA-seq analysis, distinct macrophage subsets were identified in normal and SSc-ILD lungs, and gene expression changes that occurred during the transition of normal macrophages to SPP1 macrophages were determined .