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Heidelb: A study of tuberculosis-positive conversion rates in patients with psoriasis treated with adalimus and scuqiyu
Time of Update: 2022-08-16
Dermatol Ther (Heidelb) 2022 May 26;Source: Xiao Y, Chen H, Zou Q The Tuberculosis Positive Conversion Rate Among Psoriasis Patients Treated with Adalimumab and Secukinumab: A Single-Center Retrospective Study in China.
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Arthritis Res Ther: Targeted therapy is safe and effective for elderly patients with rheumatoid arthritis
Time of Update: 2022-08-16
. In recent years, with the improvement of life prognosis in elderly patients with rheumatoid arthritis (RA), the increase in the incidence of elderly-onset RA, and the increased cumulative risk of RA in elderly women, the number of elderly RA patients has increased .
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Not just rheumatism immunity!
Time of Update: 2022-08-16
The effect of HCQ on ABT-263-induced antitumor activity was examined using three human pancreatic cancer cell lines (PANC-1, MiaPaCa-2, and BxPC-3)Results: Combination treatment of HCQ and ABT-263 synergistically reduced the viability of BxPC-3 cells alone .
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A&R: Antiphospholipid antibodies increase endometrial stromal cell decidualization, aging, and inflammation via Toll-like receptor 4, reactive oxygen species, and p38 MAPK signaling
Time of Update: 2022-08-16
. Methods : EnSCs under decidual conditions were exposed to aPL or control IgG alone, or to Toll-like receptor 4 (TLR-4) antagonist, p38 MAPK (mitogen-activated protein kinase) inhibitor, reactive oxygen species (ROS) inhibitor agents, low molecular weight heparin (LMWH), or acetylsalicylic acid .
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For rheumatoid arthritis, don’t only care about inflammation, and osteoporosis should not be underestimated!
Time of Update: 2022-08-16
The activity of cells and osteocytes adversely affects bone remodeling Glucocorticoids are a class of drugs that are widely used clinically in patients with rheumatoid arthritis.
Reducing the activity of osteoblasts and osteocytes adversely affects bone remodeling Glucocorticoids are a class of drugs that are used more clinically in patients with rheumatoid arthritis.
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A&R: The essential role of hematopoietic PAD4 in arthritis: collagen and granulocyte colony-stimulating factor-induced arthritis in the C57BL/6 mouse model
Time of Update: 2022-08-16
In the G-CSF- modified CIA model , Padi4 -/- mice developed milder arthritis, lower serum interleukin- 6 and plasma Cit-H3 levels, and synovial tissue compared with Padi4 +/+ mice Medium Cit-H4 levels were lower and microcomputed tomography showed less bone erosion .
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ARD: EULAR points for consideration for the use of imaging to guide interventional procedures in patients with rheumatic and musculoskeletal disorders (RMD)
Time of Update: 2022-08-16
The purpose of this study was to develop an evidence-based point of consideration (PtC) for the use of imaging modalities to guide interventional procedures in RMD patients .
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A&R: Central role of Semaphorin 3B in a serum-induced arthritis model and reduced levels in rheumatoid arthritis patients
Time of Update: 2022-08-16
Administration of recombinant mouse Sema3B reduced the clinical severity of serum-induced arthritis and the expression of inflammatory mediators .
Administration of recombinant mouse Sema3B reduced the clinical severity of serum-induced arthritis and the expression of inflammatory mediators .
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Is uric acid really useless?
Time of Update: 2022-08-16
In addition, a large number of studies at home and abroad in recent years have shown that there is a significant negative correlation between serum uric acid levels and the onset risk and progression of Parkinson 's disease (Parkinson's disease is a common neurodegenerative disease in the middle-aged and elderly) .
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A&R: Intensive oral uric acid lowering does not improve bone erosion scores in erosive gout patients
Time of Update: 2022-08-16
42055 Leave a comment here Objective : To determine whether intensive serum uric acid-lowering therapy improves bone erosion scores in patients with erosive gout .
42055 Leave a comment here Objective : To determine whether intensive serum uric acid-lowering therapy improves bone erosion scores in patients with erosive gout .
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A&R: Common features of anti-SSA/Ro60 antibody expression in autoimmune diseases
Time of Update: 2022-08-16
Objective : Anti- Ro autoantibodies are one of the most frequently detected autoantibodies to extractable nuclear antigens and are mainly associated with primary Sjögren's syndrome (pSS) , systemic lu
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Hydroxychloroquine, is it worth reducing the dose for safety?
Time of Update: 2022-08-16
. This study included 73 patients with stable lupus nephritis who received standard hydroxychloroquine recommended doses of the American Academy of Ophthalmology for ≥6 months and an acceptable baseline hydroxychloroquine plasma concentration (≥613.
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A&R: Efficacy advantage of low-dose benzbromarone in gout patients with insufficient renal uric acid excretion
Time of Update: 2022-08-16
Here, we compared the efficacy of first-line non-titrated, low-dose benzbromarone urate-lowering therapy with XOI ULT, a low-dose febuxostat , in gout with insufficient renal uric acid excretion .
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A&R: Dynamic changes in CpG site methylation associated with SLE subtypes in a longitudinal cohort
Time of Update: 2022-08-16
Paired t -tests were used to identify changes in 256 CpG loci previously associated with SLE subtypes as well as genome- wide .
Paired t -tests were used to identify changes in 256 CpG loci previously associated with SLE subtypes as well as genome- wide .
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Paid promotion: 1 minute to register the applet and get 20 yuan WeChat red envelope
Time of Update: 2022-08-16
Participation will be rewarded, and the inspection department will give priority to the awardAfter completing the registration, send the screenshot to the assistant to receive the reward.
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HCQ may have slight benefit for proteinuria in patients with IgA nephropathy
Time of Update: 2022-08-16
Flowchart of path selection:Flowchart of path selection:Methods: PubMed and Embase were systematically searched for studies through June 2021 comparing HCQ and other treatments to reduce proteinuria in patients with IgA nephropathy .
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A&R: B cell counts predict humoral and cellular responses to SARS-CoV-2 vaccine in patients receiving rituximab
Time of Update: 2022-08-16
. In RTX-treated patients, at least 10 B cells per microliter in the peripheral circulation are a candidate biomarker with a high likelihood of appropriate cellular and humoral responses following SARS-CoV-2 vaccination .
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A&R: Modulation of the itaconic acid pathway alleviates lupus in mice
Time of Update: 2022-08-16
Itaconic acid Itaconic acid controls inflammasome activation, type I interferon (IFN) response and oxidative stress in systemic lupus erythematosus (SLE)Methods: Female New Zealand Black/New Zealand White F1 lupus-susceptible mice were administered 4-octylitaconic acid (4-OI) or vehicle for 4 weeks after clinical onset (30 weeks of age) (10 mice/group).
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Rheumatology: Associations between psoriasis and lifestyle factors and comorbidities - a cross-sectional analysis and Mendelian randomization
Time of Update: 2022-08-16
Psoriatic Arthritis (PsA) Psoriatic Arthritis (PsA) Psoriasis Life>ComorbiditiesMETHODS: Cross-sectional data from the UK Biobank (1836 PsA, 8995 psoriasis, and 36000 controls) were analysed using logistic models adjusted for age, gender and life>BMI and smoking ) and 15 comorbidities including diabetes and coronary artery disease (CAD ) .
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Rising temperatures, be wary of rheumatism patients susceptible to shingles!
Time of Update: 2022-08-16
Symptoms may precede the onset:What should I do if there is shingles in rheumatism?What should I do if there is shingles in rheumatism?Rheumatism combined with herpes zoster has certain particularities, and there are also a few patients with atypical symptoms.
