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Tumor recurrence, chemoresistance and metastasis remain unsolved problems in cancer treatme.
Chloroquine (CQ) and hydroxychloroquine (HCQ) are known antimalarial drugs that have successfully treated autoimmune and neoplastic diseas.
They affect the Toll 9/NF-κB receptor pathway, activate stress response pathways, and enhance p53 activity and CXCR4-CXCL12 expression in cancer cel.
HCQ has positive effects in oncology research as it inhibits autophagy by deacidifying lysosomes
Schematic depicting the effect of HCQ/2-DG combination therapy:
Schematic depicting the effect of HCQ/2-DG combination therapy:Therefore, studies have explored whether the combination of the FDA-approved autophagy-inhibiting drug hydroxychloroquine (HCQ) and 2-DG is a promising therapeutic strate.
HCQ combined with 2-DG can further inhibit breast tumor cell viability and migration and induce apoptosis compared to other drugs alo.
The effect of HCQ on ABT-263-induced antitumor activity was examined using three human pancreatic cancer cell lines (PANC-1, MiaPaCa-2, and BxPC-3)
Results: Combination treatment of HCQ and ABT-263 synergistically reduced the viability of BxPC-3 cells alo.
HCQ effectively promotes apoptosis induced by Bcl-xL inhibition in BxPC-3 human pancreatic cancer cel.
HCQ can induce apoptosis, down-regulate autophagy and change the tumor microenvironment, and has great potential in the field of cancer
references:
references:De Sanctis JB, Charris J, Blanco Z, Ramírez H, Martínez GP, Mijares .
De Sanctis JB, Charris J, Blanco Z, Ramírez H, Martínez GP, Mijares .
Zhou N, Liu Q, Wang X, He L, Zhang T, Zhou H, Zhu X, Zhou T, Deng G, Qiu.
Hoque MM, Iida Y, Kotani H, Kartika ID, Harada.
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