-
Express is supported by EU CHMP, AbbVie IL-23 inhibitor is expected to gain the second indication
Time of Update: 2021-11-05
▎The content team editor of WuXi AppTec On October 15, 2021, AbbVie announced that the European Medicines Agency (EMA) Committee for Human Medicines (CHMP) recommended approval of risankizumab (trade name Skyrizi) as a single agent or combined with methylamine Pterin (MTX) is used to treat active psoriatic arthritis in adults who are inadequate or intolerant to one or more anti-rheumatic drugs (DMARDs) that change the progression of the disease .
-
NAR Human Antigen Receptor Database huARdb was published, realizing the combined analysis of clonotype and transcriptome visualization, reaching the single-cell level
Time of Update: 2021-11-05
On October 4, 2021, researcher Liu Wanlu and Professor Lu Linrong’s research group from the Joint College of the University of Edinburgh, Zhejiang University published a collaboration entitled huARdb: human Antigen Receptor database for interactive clonotype-transcriptome analysis at the single-cell level in Nucleic Acids Research.
-
Don't want to develop rheumatoid arthritis, it's right to pay attention to this antibody!
Time of Update: 2021-11-05
*Only for medical professionals' reference. In the first few years before the onset of typical symptoms of RA, patients have already produced autoantibodies in their bodies . Rheumatoid arthritis
-
[Nature] Do you know?
Time of Update: 2021-11-05
The goal of Theodora Hatziioannou and Paul Bieniasz is to identify the spikes (the protein used by SARS-CoV-2 to infect cells) that these neutralizing antibodies target in order to map out the key parts of our body that attack the virus .
-
Cell Host Microbe A new mechanism of interaction between plant immune system and auxin-secreting probiotics
Time of Update: 2021-11-05
Original link: https:// Dodds, PN & Rathjen, JP Plant immunity: towards an integrated view of plant pathogen interactions.
Original link: https:// /fulltext/S1931-3128(21)00421-2[8] Dodds, PN & Rathjen, JP Plant immunity: towards an integrated view of plant pathogen interactions.
-
Can JAK inhibitors used in RA have a place in the SLE field?
Time of Update: 2021-11-05
A study found that there are active expressions of type I interferon markers, CLE, and typical cytokines (CXCL10, MxA) and JAK2 (p-JAK2) in the skin pathology of patients with frostbite-like lupus .
Figure 9: The expression of genes related to the onset of SLE is increased in SLE patients, and decreased after treatment with Baritinib.
-
News: Orphan drug Avacopan, approved by FDA to treat ANCA-related diseases
Time of Update: 2021-11-05
At present, worldwide, there are limited studies on renal treatment options for ANCA-related vasculitis, and the mortality of patients is relatively high .
S. Food and Drug Administration (FDA) approved Avacopan to treat ANCA-related diseases (ANCA vasculitis and nephritis) .
-
JAMA: Rheumatoid arthritis relapses?
Time of Update: 2021-11-05
Relevant parties are requested to check separately when adopting or using this as a basis for decision-making .
-
The first domestic allergic asthma therapeutic antibody new drug submitted to NDA!
Time of Update: 2021-11-04
If omalizumab is approved by the National Food and Drug Administration, it is expected to become the first monoclonal antibody asthma therapy developed by a Chinese company and marketed in China .
-
New progress Quanxin Biologics QX002N injection for new indications obtained implied permission from clinical trials
Time of Update: 2021-11-04
Lupus nephritis (LN) refers to a disease in which systemic lupus erythematosus (SLE) is associated with different pathological types of immune damage in both kidneys and accompanied by clinical manifestations of obvious kidney damage .
-
I got systemic lupus erythematosus, a lot of hair loss!
Time of Update: 2021-11-04
This type of hair loss in SLE patients may indicate disease activity or worsening .
Clinical manifestations of SLE patchy alopecia: a non-scarring alopecia similar to alopecia areata, manifested as one or several, complete or incomplete alopecia spots, the scalp may be pale red or with mild erythema, and the hair follicle mouth is preserved Good, some patients may have mild itching or pain .
-
Cell subdominant antigens in tumors determine the phenotype of TCF1+CD8+T precursor cells
Time of Update: 2021-11-04
After tumor immune checkpoint suppression therapy (such as anti-PD-1), neoantigen-specific CD8+ T cells proliferate significantly, and this proliferation is positively correlated with the level of neoantigen [2]; and the adoptiveness of targeting neoantigens T cell therapy can obviously play an anti-cancer effect [3,4] .
-
[Nature] The protective effect of the immune system can be passed on to offspring?
Time of Update: 2021-11-04
They published the results of this research in an article titled "Transmission of trained immunity and heterologous resistance to infections across generations" in "Nature Immunology": Scientific research shows that what people pass to their offspring is not only written in DNA sequences.
-
10 factors + 4 questions, you can also predict organ damage in SLE patients after understanding!
Time of Update: 2021-11-04
Director Li Mengtao, Department of Rheumatology and Immunology, Peking Union Medical College Hospital, systematically summarized the related factors of systemic lupus erythematosus (SLE) organ damage .
-
Who said it can only be connected to flesh and blood?
Time of Update: 2021-11-04
*It is only for medical professionals to read for reference.
——Experts will take you to recover the bone health that you have slipped away.
This article is only used to provide scientific information to medical and health professionals, and does not represent the platform's position .
-
Sub-Journal of "Science": Red blood cells also control immunity!
Time of Update: 2021-11-04
Mangalmurti and his team from the Perelman School of Medicine at the University of Pennsylvania found that the appearance of a CpG-rich DNA molecule in the human body is associated with inflammation, and the Toll-like receptor 9 (TLR9) expressed by red blood cells can Recognize and bind this DNA, which is then recognized and cleared by macrophages, alleviating tissue damage caused by inflammation [4] .
-
What new information does the release of the new diagnosis and treatment guidelines bring to the treatment of lupus nephritis?
Time of Update: 2021-11-04
Taking the combination of hormones with MMF and TAC as an example, a single-center study by Bao Hao and others at the Nanjing General Hospital showed that this program can achieve better curative effect when used in the treatment of IV+V refractory LN, and the disease at 6 months The complete remission rate was significantly higher than that of the cyclophosphamide (CTX) group (50% vs.
-
Nature Immunology Cao Xuetao was invited to write a review on the inflammatory response prone to new coronavirus infections
Time of Update: 2021-11-04
Editor’s note iNature is China’s largest academic official account. It is jointly created by the doctoral team of Tsinghua University, Harvard University, Chinese Academy of Sciences and other units
-
Express treatment of fatal childhood immunodeficiency, initial clinical trial results of innovative gene therapy are positive
Time of Update: 2021-11-04
▎WuXi AppTec content team editor A few days ago, Rocket Pharmaceuticals announced that its research gene therapy RP-L201 has obtained positive interim data in a phase 1/2 clinical trial for the treatment of leukocyte adhesion deficiency type I (LAD-I) .
-
Nature Immunology, Zhao Yang and others found that blind mole rats use "junk DNA" to fight cancer
Time of Update: 2021-11-03
On September 23, 2021, the team of Vera Gorbunova and Andrei Seluanov of the University of Rochester in the United States published a research paper entitled Transposon-triggered innate immune response confers cancer resistance to the blind mole rat in Nature Immunology, which first revealed the anti-cancer effect of blind mole rat Mechanism .
