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Demystify!
Time of Update: 2021-11-12
Double-filtered plasma exchange The separated pathogenic plasma is filtered and separated again, and the plasma and the formed components of the blood after the pathogenic factors are discarded are infused back into the body, so as to achieve the purpose of treating diseases .
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J Genet Genomics: Genome-wide meta-analysis found 10 new psoriasis susceptibility genes in the Chinese population
Time of Update: 2021-11-12
Approximately 80 susceptibility genes have been shown to be related to psoriasis In this study, we used 5 independent data sets to conduct a meta-analysis of psoriasis genotype data in the Chinese population to explore new susceptibility loci, including 45,836 individuals with unrelated genome-wide genotypes (19,349 psoriasis patients and 26,487 healthy controls), from 5 independent epidemiological cohorts: 3 published (10M capture sequencing, Human610-Quad BeadChip, whole exome journal pre-validation sequencing) .
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Inventory of 7 types of joint cavity injection drugs, these drugs are controversial, beware!
Time of Update: 2021-11-12
Conservative treatment of rheumatology diseases such as osteoarthritis (OA) and rheumatoid arthritis , such as analgesics, oral anti-inflammatory drugs and physical therapy, may consider intra-articular injections when pain does not improve .
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Front Immunol: Gout increases the risk of cardiovascular disease in patients with psoriasis
Time of Update: 2021-11-12
We used the National Health Insurance Research Database (NHIRD) to conduct a population-based matched cohort study to investigate the relationship between gout and the incidence of cardiovascular disease in patients with PSO.
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Lancet Rheumatology: Inhibition of IL-1 and IL-6 affects the neutralizing activity of anti-SARS-CoV-2 antibodies in COVID-19 patients
Time of Update: 2021-11-12
Conclusion: IL-1 and IL-6 inhibitors used in the treatment of severe COVID-19 patients will affect the neutralizing activity of anti- SARS-CoV-2 antibodies .
Conclusion: IL-1 and IL-6 inhibitors used in the treatment of severe COVID-19 patients will affect the neutralizing activity of anti- SARS-CoV-2 antibodies .
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ARD: The relationship between two doses of COVID-19 vaccine and the onset of arthritis in patients with rheumatoid arthritis in Hong Kong
Time of Update: 2021-11-12
Real-world COVID-19 vaccine safety monitoring should continue to provide more strong evidence for the association between arthritis attacks and COVID-19 vaccines in direct disease activity testing and immunomodulatory drugs .
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ODSR: Comparison of colchicine in the treatment of acute gout.
Time of Update: 2021-11-12
The number of people who report successful treatment (50% or more pain reduction) within 32 to 36 hours, use low-dose autumn The number of people with narcissus was slightly higher than that of placebo Low-quality evidence from two trials (124 participants) (downgraded due to imprecision and prejudice) suggests that high-dose colchicine may improve symptoms compared to placebo, but increase the risk of harm .
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ARD: The safety of baritinib in the treatment of rheumatoid arthritis: the final result of a long-term extended study and comprehensive database
Time of Update: 2021-11-12
Methods: from accepting any Barry imatinib dose (All-bari-RA) patients comprehensive database ( 9 Ge III / II / Ib period and 1 long-term extension) summarizes the adverse events occurring in treatment .
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At the age of 25, why repeated acne, the truth is often not simple
Time of Update: 2021-11-12
Related laboratory results and inspections:The results showed that the patient's testosterone increased, and the patient's repeated refractory acne was a manifestation of excessive androgen, and abnormal androgen metabolism was an important cause of the onset of polycystic ovary syndrome .
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Arthritis & Rheumatology: Clinical and preclinical evidence of the role of soluble epoxide hydrolase in osteoarthritis knee pain
Time of Update: 2021-11-12
Methods: To study the potential associations between chronic knee pain in patients with OA , single nucleotide polymorphisms (SNPs) in the gene encoding sEH , and the levels of EETs and DHETs in the blood circulation .
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Arthritis & Rheumatology: First description of delayed autoinflammatory diseases caused by somatic NLRC4 chimera
Time of Update: 2021-11-12
NGS analysis did not detect any germline variants in any known AID- related genes, but the p.
NGS analysis did not detect any germline variants in any known AID- related genes, but the p.
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Application of biological agents in rheumatism and immunology
Time of Update: 2021-11-12
Adalimumab: 40 mg, once every 2 weeks, subcutaneously(2) Clinical applicationA large number of clinical trials and use have confirmed that TNF inhibitors have a good effect on RA, not only can better control the performance of joint inflammation, but also long-term use (over 6 months) may delay or even improve bone destruction .
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ARD: Crystal-induced inflammation requires mechanically sensitive TRPV4
Time of Update: 2021-11-11
Real-time quantitative RT-PCR , RNAscope in situ hybridization and Trpv4 eGFP mice are used to detect TRPV4 expression, whole-cell patch clamp recording and live cell Ca 2+ imaging are used to study TRPV4 in mouse synovial macrophages and human peripheral blood samples Functions in nuclear cells (PBMC) .
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ARD: Use methotrexate to treat rheumatoid arthritis to study whether changes in disease activity can be used as a mediator to reduce cardiovascular risk
Time of Update: 2021-11-11
This study used the Marginal Structure Model (MSM) to examine the association between the use of MTX and cardiovascular disease (CVD) in rheumatoid arthritis (RA) , and to determine whether CVD risk is mediated by changes in disease activity .
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Ann Rheum Dis: Using methotrexate to treat rheumatoid arthritis can reduce the risk of cardiovascular disease
Time of Update: 2021-11-11
A recent study published in Ann Rheum Dis, a top journal of rheumatology, analyzed the association between methotrexate (MTX) use and cardiovascular disease (CVD) in patients with rheumatoid arthritis, and determined whether the CVD risk passed Change disease activity mediated .
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ARD: METL3-mediated ATG7 m6A modification regulates the autophagy-GATA4 axis to promote cell senescence and osteoarthritis progression
Time of Update: 2021-11-11
1136/annrheumdis -2021-221091Chen X, Gong W, Shao X , et al METTL3-mediated m 6 A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression , et al 6 Annals of the Rheumatic Diseases Annals of the Rheumatic Diseases Published Online First: 27 October 2021.
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Arthritis & Rheumatology: China's genome-wide association study identifies new risk sites for Behcet's disease uveitis
Time of Update: 2021-11-11
Methods : Researchers from the National Eye Center and a number of Chongqing Medical University / Hospital collaborators conducted a genome-wide association study (GWAS) , including 978 Ming BD uveitis cases and 4388 control subjects and population in China of 953 Ming BD uveitis cases and 2129 controls were carried out replication studies .
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Nat Rev Rheumatol: Will psoriasis treatment affect the development of PSA?
Time of Update: 2021-11-11
In this study, all patients with psoriasis who were not diagnosed with PsA at baseline observed in HMO between 2000 and 2018 were monitored for the development of PsA during follow-up .
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up to date!
Time of Update: 2021-11-11
The dashed line corresponds to the rapid depolarization of the ventricular myocardium through the rapid sodium channel (INa) C: The repolarization of normal cardiomyocytes is caused by potassium ions flowing out of the cell through the HERG channel .
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[NEJM] Both are COVID-19 vaccines. What is the difference?
Time of Update: 2021-11-05
After being vaccinated with Pfizer and Moderna vaccines, the live virus neutralizing antibody, pseudovirus neutralizing antibody, and the response of the vaccinated person to the SARS-CoV-2 variant RBD and spike protein specific binding antibody continued to decline from the peak period of immunity 8 months; however, after vaccination with Johnson & Johnson vaccine, the vaccinators' antibody response to these variants is relatively stable, and even increases in some cases .
