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ARD: The safety of baritinib in the treatment of rheumatoid arthritis: the final result of a long-term extended study and comprehensive database

 Last Update: 2021-11-12
 Source: Internet
 Author: User

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Purpose: Baritinib is an oral, reversible and selective Janus kinase (JAK) 1 / JAK2 inhibitor for the treatment of rheumatoid arthritis (RA)
.

The effectiveness and safety of baritinib have been derived from previous phase II and phase III randomized controlled trials and open-label, long-term extended trials

Purpose: Baritinib is an oral, reversible and selective Janus kinase (JAK) 1 / JAK2 inhibitor for the treatment of rheumatoid arthritis (RA)

Methods: from accepting any Barry imatinib dose (All-bari-RA)patients comprehensive database ( 9 Ge III / II / Ib period and 1 long-term extension) summarizes the adverse events occurring in treatment
.

Estimated standardized incidence rate ( SIR ) and standardized mortality rate ( SMR ) of malignant tumors (excluding non-melanoma skin cancer ( NMSC ) ) .
Additional analysis was performed in a subgroup of patients who had taken 2 mg or 4 mg baritinib .

From accepting any Barry imatinib dose (All-bari-RA) integrated database of patients ( 9 Ge III / II / Ib period and 1 long-term extension) summarizes the adverse events occurring in treatment

3770 patients received baritinib ( 14 744 patient years of exposure ( PYE )

Conclusion: In this including those from 3770 patients with active RA Barry long-term data in patients with imatinib (median 4.

Source:

Taylor PC, et al.

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