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Hydroxychloroquine (HCQ) and chloroquine (CQ) are drugs used to treat systemic lupus erythematosus and rheumatoid arthritis
Hydroxychloroquine (HCQ) and chloroquine (CQ) are drugs used to treat systemic lupus erythematosus and rheumatoid arthritis
On October 26, the American College of Rheumatology (ACR) released a white paper summarizing the current understanding of hydroxychloroquine (HCQ)/chloroquine (CQ) cardiotoxicity, and proposed risk assessment and monitoring guidance based on consensus
Due to reports that HCQ and CQ have potential anti-coronavirus activity in the new crown epidemic, the use of this drug has increased in early 2020
Cardiotoxicity of HCQ/CQ
Cardiotoxicity of HCQ/CQ Cardiotoxicity of HCQ/CQHCQ and CQ interact with ventricular myocytes by blocking potassium efflux channels, leading to prolonged QT c
HCQ and CQ interact with ventricular myocytes by blocking potassium efflux channels, leading to prolonged QT c
C: The repolarization of normal cardiomyocytes is caused by potassium ions flowing out of the cell through the HERG channel
D: HCQ or CQ will cause the outflow of potassium ions to be blocked
The QT interval (referred to as QT) includes the activation time of ventricular depolarization and repolarization.
The QT interval (referred to as QT) includes the activation time of ventricular depolarization and repolarization.
High-risk groups High-risk groups
In addition to drugs, there are other factors that can prolong QT.
In addition to drugs, there are other factors that can prolong QT.
Drugs that can lead to prolonged QTc of patients Drugs that can lead to prolonged QTc of patients
If the patient has symptoms of arrhythmia, such as syncope, presyncope, or unexplained dizziness, a cardiac evaluation including an electrocardiogram should be performed in accordance with FDA label recommendations
If the patient has symptoms of arrhythmia, such as syncope, presyncope, or unexplained dizziness, a cardiac evaluation including an electrocardiogram should be performed in accordance with FDA label recommendations
The incidence of severe arrhythmia caused by hydroxychloroquine in patients with rheumatism is unclear
The incidence of severe arrhythmia caused by hydroxychloroquine in patients with rheumatism is unclear
Antimalarial therapy can reduce the amount of glucocorticoids, reduce the risk of cardiovascular disease, reduce organ damage and control the disease in the treatment of SLE disease
.
As a doctor, you should weigh the toxicity of drugs to the heart.
Although the benefits of drugs far outweigh the risks, you should also be aware of drug toxicity
.
Original: Desmarais J, Rosenbaum JT, Costenbader KH, et al.
American College of Rheumatology White Paper on Antimalarial CardiacToxicity[J].
Arthritis Rheumatol.
2021 Oct 26.
doi: 10.
1002/art.
41934.
Epubahead of print.
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