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ARD: METL3-mediated ATG7 m6A modification regulates the autophagy-GATA4 axis to promote cell senescence and osteoarthritis progression

 Last Update: 2021-11-11
 Source: Internet
 Author: User

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The long-term existence of senescent cells is closely related to the development of osteoarthritis ( OA )

Collect the synovial tissues of normal patients and OA patients

In patients and mouse models, as OA progresses, aging FLS increases significantly

This study revealed the important role of FLS senescence in the progression of OA .

Source:

Chen X, Gong W, Shao X , et al METTL3-mediated m ⁶ A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression Annals of the Rheumatic DiseasesPublished Online First: 27 October 2021.

Chen X, Gong W, Shao X , et al METTL3-mediated m ⁶ A modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression , et al ⁶Annals of the Rheumatic DiseasesAnnals of the Rheumatic DiseasesPublished Online First: 27 October 2021.
doi: 10.
1136/annrheumdis-2021-221091

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