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How to choose the TCR-Seq method? An in-depth evaluation of a 54-point SCI article is worthy of attention!
Time of Update: 2021-11-15
The data points to three high-scoring methods: mPCR-1 is a company A's platform; RACE-3 is Takara Bio's SMARTer Human TCR a/b Profiling Kit; RACE-5 is a self-made method developed by Eugster 2 et al .
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Cai Chunmei/Zheng Chunfu publishes a review of the cross-interaction of RNA and DNA recognition signaling pathways
Time of Update: 2021-11-15
Chunmei Cai of Qinghai University School of Medicine was invited to publish a review paper titled: The Crosstalk between Viral RNA and DNA Sensing Mechanisms in the journal Cellular and Molecular Life Sciences.
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Science sub-journals rewrite textbooks, red blood cells have new functions: they play an important role in innate immunity
Time of Update: 2021-11-15
Therefore, the detection and capture of nucleic acids by RBC expressing TLR9 can regulate red blood cell clearance and the production of inflammatory cytokines, proving that RBC functions as an immune sentinel under pathological conditions .
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Multiple pain in the whole body is a disease!
Time of Update: 2021-11-15
The "Guidelines for the Diagnosis and Treatment of Fibromyalgia Syndrome" (2011) pointed out that antidepressant drugs can significantly relieve pain, improve sleep, and adjust the overall state, but the effect of improving tenderness is not ideal .
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Three articles on Immunity Z-RNA editing restrict innate immunity from recognizing endogenous RNA
Time of Update: 2021-11-15
It was found that these mice spontaneously induce type I IFNs and ISGs in multiple organs and cell types, suggesting that Z-RNA editing is restricting the recognition of endogenous RNA by innate immunity The important role of aspects .
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The sore throat thought it was a minor problem, and one step later would be blind!
Time of Update: 2021-11-14
This case report demonstrates the importance of diagnosing GCA based on relatively uncommon sore throat and carotid tenderness, especially for patients with a history of polymyalgia rheumatica, in order to start treatment before the development of irreversible visual symptoms .
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Xuetao Cao’s team discovered a new molecule lncRNA-ISIR that enhances the effect of interferon
Time of Update: 2021-11-14
A research article reported on the new lncRNA discovered by the team and called it Interferon StimulatedIRF3-associating RNA (lncRNA-ISIR), and found that the lncRNA-ISIR induced by type I IFN can block The inhibitory effect of Fli-1 enhances the type I IFN response mediated by IRF3, and the positive feedback regulation mechanism of lncRNA-mediated transcription factors is proposed .
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FASEB J Liu Cuihua's team from Institute of Microbiology, Chinese Academy of Sciences and Pang Yu's team from Beijing Chest Hospital have discovered a new innate immune mechanism for tuberculosis resistant people to resist Mycobacterium tuberculosis infection
Time of Update: 2021-11-14
In recent years, it has been published in Autophagy (2021), EMBO Report (2021), Nature Communications (2019, 2017) and Nature Immunology (2015) A series of research work published in other journals has achieved important results in the interaction mechanism between pathogens and hosts, providing a variety of new ideas and potential new targets for anti-tuberculosis treatment and drug development .
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Sci Adv｜B-cell glycosylation and autoimmune diseases
Time of Update: 2021-11-14
The Richard Cummings laboratory of the Harvard Medical School Beth Israel Deaconess Medical Center (BIDMC) published a research article titled Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance in Science Advances on October 6, 2021.
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ARD: Inhibit the effectiveness of IL-12/23 (Utekinumab) and tumor necrosis factor in psoriatic arthritis
Time of Update: 2021-11-13
The purpose of the study was to evaluate the effectiveness of ustekinumab and tumor necrosis factor inhibitor (TNFi) in patients with PsA for 6 months, and to analyze the predictive factors of low disease activity (LDA) or remission .
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Science/Hepatology/STTT Academician Tian Zhigang and other teams have made continuous progress in the field of immunology
Time of Update: 2021-11-13
On September 12, 2021, University of Science and Technology of China Peng Hui, Tian Zhigang and Sun Xun jointly published a research paper entitled "Requirement of RORα for Maintenance and Anti-Tumor Immunity of Liver-Resident Natural Killer Cells/ILC1s" in Hepatology Online The study found that RORα is highly expressed in liver-resident NK (LrNK) cells/ILC1s .
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Super finishing!
Time of Update: 2021-11-13
Indications : This type of drug has the effects of rapid anti-inflammatory and control of disease activity in RA patients, preventing bone destruction and alleviating the disease .
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New recommendations for the management of lupus nephritis, do you know these two new therapies?
Time of Update: 2021-11-13
The combination of immunosuppressive drugs and Voclosporin or belimumab can give patients a better prognosis within 1-2 years (Figure 1) .
Voclosporin and belimumab can effectively increase the rate of complete remission and partial remission, and improve the long-term prognosis of patients .
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ARD: Prospective analysis of ultrasound dizziness as a potential monitoring tool for patients with giant cell arteritis
Time of Update: 2021-11-13
Evaluation of new diagnostic diagnostic GCA patients halo ultrasonic sensitivity to changes in its characteristics and disease activity and glucocorticoids (GC) related to treatment Methods: A prospective study of ultrasound-confirmed GCA patients undergoing continuous ultrasound evaluation of temporal artery (TA) and axillary artery (AX) at fixed time points .
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Huang Ailong's team from Chongqing Medical University discovered 3 super-strong antibodies against the Delta strain
Time of Update: 2021-11-13
On November 4, Chongqing Medical University announced that Professor Huang Ailong of the school led the emergency response team of the new coronavirus and discovered 3 super-strong antibodies with broad-spectrum neutralizing activity against multiple mutant strains of the new coronavirus.
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Arthritis&Rheumatology: Relationship between pregnancy outcome of women with psoriatic arthritis and anti-rheumatic treatment and timing
Time of Update: 2021-11-12
PsA pregnancy receiving anti-rheumatic treatment during pregnancy has the greatest increased risk of preterm birth compared with non- PsA pregnancy ( aOR 2.
PsA pregnancy receiving anti-rheumatic treatment during pregnancy has the greatest increased risk of preterm birth compared with non- PsA pregnancy ( aOR 2.
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Lancet Rheumatology: Diagnostic accuracy of vascular ultrasound in patients with suspected giant cell arteritis (EUREKA): a prospective, multicenter, non-interventional cohort study
Time of Update: 2021-11-12
Of the 12 patients with positive ultrasound but negative temporal artery biopsy, 7 cases ( 58% ) were confirmed to have macrovascular giant cell arteritis by other imaging studies .
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J Dermatolog Treat: Differences in medical disorders of psoriasis patients due to race and/or ethnic background
Time of Update: 2021-11-12
Recently, a study published in J Dermatolog Treat evaluated whether the gap in psoriasis care is due to differences in understanding of psoriasis and/or medical disorders based on race or ethnic background .
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CDSR: Research on the treatment of tophi in patients with gout
Time of Update: 2021-11-12
Moderately certain evidence (2 studies; 103 participants) showed that compared with placebo plus purinol group (16/50), Lesinurad 200 mg plus allopurinol group (11/53) had complete targeted tophi There is no clinically significant difference in regression (RR 0.
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Favorite posts!
Time of Update: 2021-11-12
2018 Chinese Rheumatoid Arthritis Diagnosis and Treatment Guidelines[J].
9. Gossec L, Baraliakos X, Kerschbaumer A, et al EULAR recommendations for the management of psoriatic arthritis with pharmacological therapies: 2019 update Annals of the Rheumatic Diseases 2020;79 :700-712.
