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Multiple pain in the whole body is a disease!
Time of Update: 2021-11-15
The "Guidelines for the Diagnosis and Treatment of Fibromyalgia Syndrome" (2011) pointed out that antidepressant drugs can significantly relieve pain, improve sleep, and adjust the overall state, but the effect of improving tenderness is not ideal .
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Cai Chunmei/Zheng Chunfu publishes a review of the cross-interaction of RNA and DNA recognition signaling pathways
Time of Update: 2021-11-15
Chunmei Cai of Qinghai University School of Medicine was invited to publish a review paper titled: The Crosstalk between Viral RNA and DNA Sensing Mechanisms in the journal Cellular and Molecular Life Sciences.
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Three articles on Immunity Z-RNA editing restrict innate immunity from recognizing endogenous RNA
Time of Update: 2021-11-15
It was found that these mice spontaneously induce type I IFNs and ISGs in multiple organs and cell types, suggesting that Z-RNA editing is restricting the recognition of endogenous RNA by innate immunity The important role of aspects .
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How to choose the TCR-Seq method? An in-depth evaluation of a 54-point SCI article is worthy of attention!
Time of Update: 2021-11-15
The data points to three high-scoring methods: mPCR-1 is a company A's platform; RACE-3 is Takara Bio's SMARTer Human TCR a/b Profiling Kit; RACE-5 is a self-made method developed by Eugster 2 et al .
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Science sub-journals rewrite textbooks, red blood cells have new functions: they play an important role in innate immunity
Time of Update: 2021-11-15
Therefore, the detection and capture of nucleic acids by RBC expressing TLR9 can regulate red blood cell clearance and the production of inflammatory cytokines, proving that RBC functions as an immune sentinel under pathological conditions .
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The sore throat thought it was a minor problem, and one step later would be blind!
Time of Update: 2021-11-14
This case report demonstrates the importance of diagnosing GCA based on relatively uncommon sore throat and carotid tenderness, especially for patients with a history of polymyalgia rheumatica, in order to start treatment before the development of irreversible visual symptoms .
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Xuetao Cao’s team discovered a new molecule lncRNA-ISIR that enhances the effect of interferon
Time of Update: 2021-11-14
A research article reported on the new lncRNA discovered by the team and called it Interferon StimulatedIRF3-associating RNA (lncRNA-ISIR), and found that the lncRNA-ISIR induced by type I IFN can block The inhibitory effect of Fli-1 enhances the type I IFN response mediated by IRF3, and the positive feedback regulation mechanism of lncRNA-mediated transcription factors is proposed .
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Sci Adv|B-cell glycosylation and autoimmune diseases
Time of Update: 2021-11-14
The Richard Cummings laboratory of the Harvard Medical School Beth Israel Deaconess Medical Center (BIDMC) published a research article titled Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance in Science Advances on October 6, 2021.
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FASEB J Liu Cuihua's team from Institute of Microbiology, Chinese Academy of Sciences and Pang Yu's team from Beijing Chest Hospital have discovered a new innate immune mechanism for tuberculosis resistant people to resist Mycobacterium tuberculosis infection
Time of Update: 2021-11-14
In recent years, it has been published in Autophagy (2021), EMBO Report (2021), Nature Communications (2019, 2017) and Nature Immunology (2015) A series of research work published in other journals has achieved important results in the interaction mechanism between pathogens and hosts, providing a variety of new ideas and potential new targets for anti-tuberculosis treatment and drug development .
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Science/Hepatology/STTT Academician Tian Zhigang and other teams have made continuous progress in the field of immunology
Time of Update: 2021-11-13
On September 12, 2021, University of Science and Technology of China Peng Hui, Tian Zhigang and Sun Xun jointly published a research paper entitled "Requirement of RORα for Maintenance and Anti-Tumor Immunity of Liver-Resident Natural Killer Cells/ILC1s" in Hepatology Online The study found that RORα is highly expressed in liver-resident NK (LrNK) cells/ILC1s .
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ARD: Inhibit the effectiveness of IL-12/23 (Utekinumab) and tumor necrosis factor in psoriatic arthritis
Time of Update: 2021-11-13
The purpose of the study was to evaluate the effectiveness of ustekinumab and tumor necrosis factor inhibitor (TNFi) in patients with PsA for 6 months, and to analyze the predictive factors of low disease activity (LDA) or remission .
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New recommendations for the management of lupus nephritis, do you know these two new therapies?
Time of Update: 2021-11-13
The combination of immunosuppressive drugs and Voclosporin or belimumab can give patients a better prognosis within 1-2 years (Figure 1) .
Voclosporin and belimumab can effectively increase the rate of complete remission and partial remission, and improve the long-term prognosis of patients .
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Super finishing!
Time of Update: 2021-11-13
Indications : This type of drug has the effects of rapid anti-inflammatory and control of disease activity in RA patients, preventing bone destruction and alleviating the disease .
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Huang Ailong's team from Chongqing Medical University discovered 3 super-strong antibodies against the Delta strain
Time of Update: 2021-11-13
On November 4, Chongqing Medical University announced that Professor Huang Ailong of the school led the emergency response team of the new coronavirus and discovered 3 super-strong antibodies with broad-spectrum neutralizing activity against multiple mutant strains of the new coronavirus.
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ARD: Prospective analysis of ultrasound dizziness as a potential monitoring tool for patients with giant cell arteritis
Time of Update: 2021-11-13
Evaluation of new diagnostic diagnostic GCA patients halo ultrasonic sensitivity to changes in its characteristics and disease activity and glucocorticoids (GC) related to treatment Methods: A prospective study of ultrasound-confirmed GCA patients undergoing continuous ultrasound evaluation of temporal artery (TA) and axillary artery (AX) at fixed time points .
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Arthritis&Rheumatology: Relationship between pregnancy outcome of women with psoriatic arthritis and anti-rheumatic treatment and timing
Time of Update: 2021-11-12
PsA pregnancy receiving anti-rheumatic treatment during pregnancy has the greatest increased risk of preterm birth compared with non- PsA pregnancy ( aOR 2.
PsA pregnancy receiving anti-rheumatic treatment during pregnancy has the greatest increased risk of preterm birth compared with non- PsA pregnancy ( aOR 2.
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J Genet Genomics: Genome-wide meta-analysis found 10 new psoriasis susceptibility genes in the Chinese population
Time of Update: 2021-11-12
Approximately 80 susceptibility genes have been shown to be related to psoriasis In this study, we used 5 independent data sets to conduct a meta-analysis of psoriasis genotype data in the Chinese population to explore new susceptibility loci, including 45,836 individuals with unrelated genome-wide genotypes (19,349 psoriasis patients and 26,487 healthy controls), from 5 independent epidemiological cohorts: 3 published (10M capture sequencing, Human610-Quad BeadChip, whole exome journal pre-validation sequencing) .
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Lancet Rheumatology: Diagnostic accuracy of vascular ultrasound in patients with suspected giant cell arteritis (EUREKA): a prospective, multicenter, non-interventional cohort study
Time of Update: 2021-11-12
Of the 12 patients with positive ultrasound but negative temporal artery biopsy, 7 cases ( 58% ) were confirmed to have macrovascular giant cell arteritis by other imaging studies .
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Demystify!
Time of Update: 2021-11-12
Double-filtered plasma exchange The separated pathogenic plasma is filtered and separated again, and the plasma and the formed components of the blood after the pathogenic factors are discarded are infused back into the body, so as to achieve the purpose of treating diseases .
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Inventory of 7 types of joint cavity injection drugs, these drugs are controversial, beware!
Time of Update: 2021-11-12
Conservative treatment of rheumatology diseases such as osteoarthritis (OA) and rheumatoid arthritis , such as analgesics, oral anti-inflammatory drugs and physical therapy, may consider intra-articular injections when pain does not improve .