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This article is reproduced from the WeChat public account of "China Biotechnology Network"
.
On November 4, Chongqing Medical University announced that Professor Huang Ailong of the school led the emergency response team of the new coronavirus and discovered 3 super-strong antibodies with broad-spectrum neutralizing activity against multiple mutant strains of the new coronavirus.
The antibodies are extremely contagious.
The Delta strain also showed strong neutralizing ability
.
The research results were published online in the top international journal "Nature Communications" on November 2 with the title "Super neutralizing antibodies with protective effects against multiple mutant strains of the new coronavirus"
.
The global spread of the new crown virus poses a serious threat to human health and social economy
.
At present, various countries have developed a variety of new crown vaccines, which have effectively controlled the incidence of moderate to severe diseases
.
However, after the new coronavirus "battled" with neutralizing antibodies, multiple mutant strains continued to appear
.
Among them, the mutant strains represented by the α mutant strain that first appeared in the UK, the β mutant strain in South Africa and the Delta strain in India are highly infectious and aggressive
.
These mutant strains can even break through the vaccine's epidemic prevention and cause human infections and spread quickly
.
At present, the world has not yet developed an effective drug to fight the new coronavirus
.
Therefore, it is necessary to develop new broad-spectrum antibody drugs against multiple mutant strains of the new coronavirus
.
Under the leadership of two professors, Huang Ailong and Jin Aishun, the school’s new crown virus emergency response team has cooperated with Fudan University, Shanghai University of Science and Technology and Wuhan Institute of Virology.
The single-cell cloning technology screened out more than 200 specific antibodies against RBD (the key part of the virus entering the cell) from the blood of dozens of recovered patients during the recovery period
.
Finally, the team screened three antibodies with the strongest neutralizing activity
.
These three antibodies are not affected by the new coronavirus mutant strain, and still have the function of blocking the passage of the virus into the body
.
Through live virus experiments in vivo and in vitro, the team confirmed that these three antibodies exert a powerful blocking and protective effect on highly vigorous virus mutant strains such as the Delta strain and the South African strain
.
Moreover, due to the different targets of these antibodies, they can also work together to prevent the rapid mutation of the virus-just like the front, center and defender in a team, they can jointly defend and deal with the emergence of new mutant strains ( Offense)
.
"These three antibodies are super-strong antibodies with broad-spectrum neutralization activity against multiple mutant strains of the new coronavirus.
They have the dual characteristics of preventive drugs and therapeutic drugs, and have huge clinical application prospects
.
" Huang Ailong said, the screened Three antibodies can be manufactured through genetic engineering to achieve large-scale production
.
At present, Zhongyi is working with internationally renowned antiviral drug experts to jointly develop related drugs, and it is expected to enter clinical research early next year
.
End reference materials: [1]https:// Selected onlookers in the past subvert cognition! Science sub-publishes reveal the "new identity" of red blood cells: not only oxygen "porters", or human immune "sentinels" that are too hot and sore muscles? Don't worry, Science reveals the secret of self-repair of damaged muscles.
Nature: Why is it easy to gain weight by drinking milk tea? Fructose promotes the growth of intestinal villi and accumulates fat.
eLife: Cat skin bacteria may be used to treat human skin infections.
Cell Journal: Cold may successfully defend against autoimmune diseases! Medical immunotherapy| Biosimilars| Vaccines| Drug resistance| Drug targets| Healthy life| Pharmaceutical company news| Drug inventory| Pharmaceutical technology| Basic research on side effects of drugs/ Translational medicine leukemia| Lung cancer| Gastric cancer| Colorectal cancer| Liver cancer| Breast Cancer | Pancreatic Cancer | Cardiovascular Diseases | Neurodegenerative Diseases | Intestinal Microbial Medical Devices / Biotechnology In Vitro Diagnosis | Medical Devices | Bio-Nano | 3D Printing | Gene Testing | Single Cell Sequencing | Gene Editing | Assisted Reproduction | Artificial Intelligence | Precision medicine policy anti-cancer drugs | 4+7 volume procurement | Consumables | Filing system | Registrant system | Healthy China | New version of the basic medicine catalog | AI medical devices | Telemedicine | Same stock market with different rights / capital IPO | Financing | Cooperation | Funds | Hong Kong Stock Exchange | Science and Technology Innovation Board | Growth Enterprise Market | R & D Investment | Acquisitions | Market & Consumption
.
On November 4, Chongqing Medical University announced that Professor Huang Ailong of the school led the emergency response team of the new coronavirus and discovered 3 super-strong antibodies with broad-spectrum neutralizing activity against multiple mutant strains of the new coronavirus.
The antibodies are extremely contagious.
The Delta strain also showed strong neutralizing ability
.
The research results were published online in the top international journal "Nature Communications" on November 2 with the title "Super neutralizing antibodies with protective effects against multiple mutant strains of the new coronavirus"
.
The global spread of the new crown virus poses a serious threat to human health and social economy
.
At present, various countries have developed a variety of new crown vaccines, which have effectively controlled the incidence of moderate to severe diseases
.
However, after the new coronavirus "battled" with neutralizing antibodies, multiple mutant strains continued to appear
.
Among them, the mutant strains represented by the α mutant strain that first appeared in the UK, the β mutant strain in South Africa and the Delta strain in India are highly infectious and aggressive
.
These mutant strains can even break through the vaccine's epidemic prevention and cause human infections and spread quickly
.
At present, the world has not yet developed an effective drug to fight the new coronavirus
.
Therefore, it is necessary to develop new broad-spectrum antibody drugs against multiple mutant strains of the new coronavirus
.
Under the leadership of two professors, Huang Ailong and Jin Aishun, the school’s new crown virus emergency response team has cooperated with Fudan University, Shanghai University of Science and Technology and Wuhan Institute of Virology.
The single-cell cloning technology screened out more than 200 specific antibodies against RBD (the key part of the virus entering the cell) from the blood of dozens of recovered patients during the recovery period
.
Finally, the team screened three antibodies with the strongest neutralizing activity
.
These three antibodies are not affected by the new coronavirus mutant strain, and still have the function of blocking the passage of the virus into the body
.
Through live virus experiments in vivo and in vitro, the team confirmed that these three antibodies exert a powerful blocking and protective effect on highly vigorous virus mutant strains such as the Delta strain and the South African strain
.
Moreover, due to the different targets of these antibodies, they can also work together to prevent the rapid mutation of the virus-just like the front, center and defender in a team, they can jointly defend and deal with the emergence of new mutant strains ( Offense)
.
"These three antibodies are super-strong antibodies with broad-spectrum neutralization activity against multiple mutant strains of the new coronavirus.
They have the dual characteristics of preventive drugs and therapeutic drugs, and have huge clinical application prospects
.
" Huang Ailong said, the screened Three antibodies can be manufactured through genetic engineering to achieve large-scale production
.
At present, Zhongyi is working with internationally renowned antiviral drug experts to jointly develop related drugs, and it is expected to enter clinical research early next year
.
End reference materials: [1]https:// Selected onlookers in the past subvert cognition! Science sub-publishes reveal the "new identity" of red blood cells: not only oxygen "porters", or human immune "sentinels" that are too hot and sore muscles? Don't worry, Science reveals the secret of self-repair of damaged muscles.
Nature: Why is it easy to gain weight by drinking milk tea? Fructose promotes the growth of intestinal villi and accumulates fat.
eLife: Cat skin bacteria may be used to treat human skin infections.
Cell Journal: Cold may successfully defend against autoimmune diseases! Medical immunotherapy| Biosimilars| Vaccines| Drug resistance| Drug targets| Healthy life| Pharmaceutical company news| Drug inventory| Pharmaceutical technology| Basic research on side effects of drugs/ Translational medicine leukemia| Lung cancer| Gastric cancer| Colorectal cancer| Liver cancer| Breast Cancer | Pancreatic Cancer | Cardiovascular Diseases | Neurodegenerative Diseases | Intestinal Microbial Medical Devices / Biotechnology In Vitro Diagnosis | Medical Devices | Bio-Nano | 3D Printing | Gene Testing | Single Cell Sequencing | Gene Editing | Assisted Reproduction | Artificial Intelligence | Precision medicine policy anti-cancer drugs | 4+7 volume procurement | Consumables | Filing system | Registrant system | Healthy China | New version of the basic medicine catalog | AI medical devices | Telemedicine | Same stock market with different rights / capital IPO | Financing | Cooperation | Funds | Hong Kong Stock Exchange | Science and Technology Innovation Board | Growth Enterprise Market | R & D Investment | Acquisitions | Market & Consumption
