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A&R: Dynamic changes in CpG site methylation associated with SLE subtypes in a longitudinal cohort

 Last Update: 2022-08-16
 Source: Internet
 Author: User

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Background/Aim: A cross- sectional study revealed the association between DNA methylation and systemic lupus erythematosus (SLE) outcom.

A cross- sectional study reveals an association between DNA methylation and systemic lupus erythematosus (SLE) outcom.

Methods: 101 participants from the California Lupus Epidemiology Study were studie.

The study was conducted on 101 participantsfrom the California Lupus Epidemiology Stud.

Most CpGs previously associated with SLE subtypes remained stable over two years ( 185 CpGs (73%) , t -test FDR >05 .

In this SLE longitudinal cohort, we identified a subset of SLE subtype-associated CpGs that are stable over time and potentially useful as biomarkers of disease subtyp.

Lanata, CM, Nititham,.
, Taylor, KE, Solomon,.
, Chung, SA, Blazer,.
, Trupin,.
, Katz,.
, Dall'Era,.
, Yazdany,.
, Sirota ,.
, Barcellos, LF and Criswell, LA (2022), The dynamics of methylation of CpG sites associated with SLE subtypes in a longitudinal coho.
Arthritis Rheumat.
Accepted Author Manuscri.

https://d.

org/11002/a.

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